寻找线粒体DNA聚合酶γ基因（POLG）中CAG重复多态性与结直肠癌的关联。
Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer.
作者信息
Linkowska Katarzyna, Jawień Arkadiusz, Marszałek Andrzej, Skonieczna Katarzyna, Grzybowski Tomasz
机构信息
The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Institute of Forensic Medicine, Department of Molecular and Forensic Genetics, Bydgoszcz, Poland.
The Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Chair of Vascular Surgery and Angiology, Bydgoszcz, Poland.
出版信息
Acta Biochim Pol. 2015;62(3):625-7. doi: 10.18388/abp.2014_935. Epub 2015 Aug 28.
Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome. Recent studies demonstrated an association of CAG repeat polymorphism in the second exon of POLG gene with the risk of cancer. We investigated the CAG repeat variability in the POLG gene in tumor and non-tumor tissues from colorectal cancer patients and in DNA samples isolated from blood obtained from age-matched healthy persons. Somatically occuring CAG-repeat alterations in cancer tissues have been observed in 10% of patients, but no association has been found between the CAG repeat variants in the POLG gene and colorectal cancer risk.
线粒体DNA聚合酶γ（POLG）是唯一参与维持线粒体基因组的DNA聚合酶。最近的研究表明，POLG基因第二外显子中的CAG重复多态性与癌症风险相关。我们研究了来自结直肠癌患者的肿瘤组织和非肿瘤组织以及从年龄匹配的健康人血液中分离的DNA样本中POLG基因的CAG重复变异性。在10%的患者中观察到癌组织中存在体细胞性CAG重复改变，但未发现POLG基因中的CAG重复变异与结直肠癌风险之间存在关联。
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