Shuwen Han, Xi Yang, Yuefen Pan
Huzhou Central Hospital, No. 198 Hongqi Road, Huzhou, Zhejiang 313000, China.
Dis Markers. 2017;2017:5189803. doi: 10.1155/2017/5189803. Epub 2017 Mar 16.
Colorectal cancer (CRC) was one of the most frequent cancers worldwide. Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion contains its own DNA and regulates self-replicating so that it can be as a candidate biomarker for evaluating the risk and prognosis of colorectal cancer. But there were already huge controversies on this issue. The review was to summarize current viewpoints of the controversial issues and described our understanding from the four aspects including mtDNA copy number, mitochondrial displacement loop, mtDNA variation, and mtDNA microsatellite instability, wishing the summary of the mtDNA in colorectal cancer could provide a meaningful reference or a valuable direction in the future studies.
结直肠癌（CRC）是全球最常见的癌症之一。准确的风险和预后评估可为患者带来更好的生活质量和更长的生存时间。当前的研究热点集中在用于评估风险和预后的基因生物标志物上。线粒体含有自身的DNA并调节自我复制，因此它可作为评估结直肠癌风险和预后的候选生物标志物。但在这个问题上已经存在巨大争议。本综述旨在总结这些争议问题的当前观点，并从线粒体DNA拷贝数、线粒体置换环、线粒体DNA变异和线粒体DNA微卫星不稳定性这四个方面阐述我们的理解，希望对结直肠癌中线粒体DNA的总结能为未来研究提供有意义的参考或有价值的方向。
