Lammers-van der Holst Heidi M, Kerkhof Gerard A
a Department of Psychology , University of Amsterdam , Amsterdam , The Netherlands and .
b Center for Sleep/Wake Disorders , MCH Westeinde Hospital, The Hague , The Netherlands.
Chronobiol Int. 2015;32(8):1162-7. doi: 10.3109/07420528.2015.1064130. Epub 2015 Aug 28.
Cortisol acts as a critical biological intermediary through which chronic stressors like shift work impact upon multiple physiological, neuro-endocrine and hormonal functions. Therefore, the cortisol awakening response (CAR) is suggested as a prime index of shift work tolerance. Repeated assessments of the CAR (calculated as MnInc) in a group of 25 young novice police officers showed that in the interval between about 4 and 14 months after transitioning from regular day work to rotating shift work, mean values began to rise from baseline to significantly higher levels at about 14 months after they commenced shift work. Visual inspection of the individual trends revealed that a subgroup of 10 subjects followed a monotonically rising trend, whereas another 14 subjects, after an initial rise from about 4-14 months, reverted to a smaller, baseline level cortisol response at about 20 months after the start of shift work. If the initial increase in the cortisol response marks the development of a chronic stress response, the subsequent reversal to baseline levels in the subgroup of 14 participants might be indicative of a process of recovery, possibly the development of shift work tolerance.
皮质醇作为一种关键的生物中介物，通过它，诸如轮班工作等慢性应激源会影响多种生理、神经内分泌和激素功能。因此，皮质醇觉醒反应（CAR）被认为是轮班工作耐受性的主要指标。对一组25名年轻的新手警察进行的CAR（计算为MnInc）重复评估显示，在从常规日班工作过渡到轮班工作后的大约4至14个月间隔内，平均值从基线开始上升，在开始轮班工作约14个月后显著升高至更高水平。对个体趋势的直观检查显示，10名受试者的一个亚组呈现单调上升趋势，而另外14名受试者在最初从大约4 - 14个月上升后，在开始轮班工作约20个月后恢复到较小的、基线水平的皮质醇反应。如果皮质醇反应的最初增加标志着慢性应激反应的发展，那么14名参与者亚组中随后恢复到基线水平可能表明恢复过程，可能是轮班工作耐受性的发展。
