Ramprasath Vanu Ramkumar, Jones Peter J H
a Richardson Centre for Functional Foods and Nutraceuticals , Winnipeg , Canada.
b Department of Human Nutritional Sciences , University of Manitoba , Winnipeg , Canada.
J Diet Suppl. 2016;13(4):353-67. doi: 10.3109/19390211.2015.1036190. Epub 2015 Aug 28.
The objective was to determine safety and efficacy of health supplements "Beyond Tangy Tangerine," a multivitamin/mineral complex and combination of multivitamin/mineral complex, "Osteofx," a bone healthy supplement and "Ultimate Essential Fatty Acids" in Sprague Dawley rats consuming high-fat diets. Initially a pilot study was conducted which confirmed palatability and acceptability of supplements. In a second study, rats (n = 15/group) were randomized to Control; Multivitamin/mineral complex (2 g/kg BW) or Combination (2 g Multivitamin/mineral complex, 1.5 g Bone healthy supplement and 0.34 g Essential fatty acids/kg BW). No differences were observed in BW change, feed intake, organ weights or bone mineral composition with supplementations compared to control. Multivitamin/mineral complex supplementation decreased abdominal white adipose tissue weights (WAT) (p = .005), total (p = .033) and fat mass (p = .040), plasma IL-6 (p = .016) and ALKP (p = .038) and elevated plasma calcium (p < .001), phosphorus (p = .038), total protein (p = .002), albumin (p = .014) and globulin (p = .018), compared to control. Similarly, combination supplementation reduced WAT (p < .001), total (p = .023) and fat mass (p = .045), plasma triglycerides (p = .018), IL-6 (p = .002) and ALKP (p < .001) with increases in plasma calcium (p = .031), phosphorus (p < .001) compared to control. Results indicate that consuming either supplement can be considered safe and improves overall health by reducing inflammation, abdominal fat mass and plasma triglycerides, as well as promote bone health.
目的是确定健康补充剂“Beyond Tangy Tangerine”（一种多种维生素/矿物质复合物）、“Osteofx”（一种骨骼健康补充剂）和“Ultimate Essential Fatty Acids”在食用高脂饮食的斯普拉格-道利大鼠中的安全性和有效性。最初进行了一项初步研究，证实了这些补充剂的适口性和可接受性。在第二项研究中，将大鼠（每组n = 15只）随机分为对照组；多种维生素/矿物质复合物组（2 g/kg体重）或组合组（2 g多种维生素/矿物质复合物、1.5 g骨骼健康补充剂和0.34 g必需脂肪酸/kg体重）。与对照组相比，补充剂在体重变化、采食量、器官重量或骨矿物质组成方面未观察到差异。与对照组相比，补充多种维生素/矿物质复合物可降低腹部白色脂肪组织重量（WAT）（p = 0.005）、总体重（p = 0.033）和脂肪量（p = 0.040）、血浆白细胞介素-6（IL-6）（p = 0.016）和碱性磷酸酶（ALKP）（p = 0.038），并提高血浆钙（p < 0.001）、磷（p = 0.038）、总蛋白（p = 0.002）、白蛋白（p = 0.014）和球蛋白（p = 0.018）。同样，与对照组相比，组合补充剂可降低WAT（p < 0.001）、总体重（p = 0.023）和脂肪量（p = 0.045）、血浆甘油三酯（p = 0.018）、IL-6（p = 0.002）和ALKP（p < 0.001），同时血浆钙（p = 0.031）、磷（p < 0.001）升高。结果表明，食用任何一种补充剂都可被认为是安全的，并且通过减轻炎症、腹部脂肪量和血浆甘油三酯来改善整体健康状况，同时促进骨骼健康。
