癌症治疗中的 DNA 甲基化抑制剂：免疫维度。
DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.
机构信息
Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, 303 East Superior Street, Lurie 5-123, Chicago, IL 60611, USA.
出版信息
Cell. 2015 Aug 27;162(5):938-9. doi: 10.1016/j.cell.2015.08.005.
PMID:26317460
Abstract
DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retroviral sequences.
摘要
DNA 去甲基化剂已获准用于某些血液恶性肿瘤，并正在实体肿瘤中进行积极研究，但这些药物的作用机制仍不清楚。在本期《细胞》杂志上，两组研究人员表明，这些药物通过转录激活内源性逆转录病毒序列，激活一种有毒的细胞抗病毒程序。
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