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通往 RNA 外切体的门户

Gateway Arch to the RNA Exosome.

机构信息

Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston and The University of Texas Graduate School of Biomedical Sciences, 6431 Fannin Street, MSB 1.212, Houston, TX 77030, USA.

Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston and The University of Texas Graduate School of Biomedical Sciences, 6431 Fannin Street, MSB 1.212, Houston, TX 77030, USA.

出版信息

Cell. 2015 Aug 27;162(5):940-1. doi: 10.1016/j.cell.2015.08.013.

DOI:10.1016/j.cell.2015.08.013
PMID:26317461
Abstract

The RNA exosome degrades many different RNAs. Thoms et al. now fill an important gap in our understanding of how the exosome recognizes distinct subsets of target RNAs.

摘要

RNA 外切体降解许多不同的 RNA。Thom 等人现在填补了我们对外切体如何识别不同靶 RNA 子集的理解中的一个重要空白。

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Gateway Arch to the RNA Exosome.通往 RNA 外切体的门户
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2
The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins.外切体通过特定衔接蛋白被招募到 RNA 底物上。
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Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase.酵母Mpp6-核外切体复合物的结构与重组表明,Mpp6刺激RNA衰变并招募Mtr4解旋酶。
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Depletion of the yeast nuclear exosome subunit Rrp6 results in accumulation of polyadenylated RNAs in a discrete domain within the nucleolus.酵母细胞核外切体亚基Rrp6的缺失导致聚腺苷酸化RNA在核仁内的一个离散区域积累。
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引用本文的文献

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Post-Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs.基因表达的转录后调控与真核生物mRNA的复杂生命历程
Wiley Interdiscip Rev RNA. 2025 Mar-Apr;16(2):e70007. doi: 10.1002/wrna.70007.
2
Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex.MTR4-ZCCHC8 相互作用的结构基础,刺激核 exosome 靶向复合物中的 MTR4 解旋酶。
Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5506-E5515. doi: 10.1073/pnas.1803530115. Epub 2018 May 29.
3
Ribosomal RNA Biogenesis and Its Response to Chilling Stress in .
核糖体 RNA 的生物发生及其对. 冷胁迫的响应。
Plant Physiol. 2018 May;177(1):381-397. doi: 10.1104/pp.17.01714. Epub 2018 Mar 19.
4
Noncoding RNA Surveillance: The Ends Justify the Means.非编码 RNA 监测:手段决定目的。
Chem Rev. 2018 Apr 25;118(8):4422-4447. doi: 10.1021/acs.chemrev.7b00462. Epub 2017 Oct 12.
5
Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors.靶向RNA以便由真核RNA外切体及其辅助因子进行加工或降解。
Genes Dev. 2017 Jan 15;31(2):88-100. doi: 10.1101/gad.294769.116.