Huang Weirong, Zhang Penghua, Xu Hui, Chang Shengli, He Yongju, Wang Fei, Liang Gaowei
Laboratory of Nano-Biology Technology, Central South University, Changsha, 410083, People's Republic of China. School of Physics and Electronics Changsha University of Science and Technology, Changsha, 410004, People's Republic of China.
Nanotechnology. 2015 Sep 25;26(38):385101. doi: 10.1088/0957-4484/26/38/385101. Epub 2015 Aug 28.
The lead ion concentration in bile is considerably higher than in blood, and bile is released into the alimentary tract. Thiol-modified SBA-15 administered orally can combine with lead ions in the alimentary tract. In this paper, the in vitro lead absorption of bile was investigated. This thiol-modified SBA-15 material was used in pharmacodynamics studies on rabbits. The result that the lead content in faeces was notably higher indicates that thiol-modified SBA-15 can efficiently remove lead. The mechanism could include the following: thiol-modified SBA-15 material cuts off the heavy metal lead recirculation in the process of bile enterohepatic circulation by chelating the lead in the alimentary tract, causing a certain proportion of lead to be removed by the thiol mesoporous material, and the lead is subsequently egested out of the body in faeces. The results indicate that this material might be a potential non-injection material for the removal bodily heavy metal lead in the alimentary tract. This material may also be a useful means of lead removal, especially for non-acute sub-poisoning symptoms.
胆汁中的铅离子浓度远高于血液，且胆汁会排入消化道。口服硫醇修饰的SBA-15可与消化道中的铅离子结合。本文研究了胆汁对铅的体外吸收情况。这种硫醇修饰的SBA-15材料用于兔子的药效学研究。粪便中铅含量显著升高的结果表明硫醇修饰的SBA-15能有效去除铅。其机制可能如下：硫醇修饰的SBA-15材料通过螯合消化道中的铅，切断胆汁肠肝循环过程中的重金属铅再循环，使一定比例的铅被硫醇介孔材料去除，随后铅随粪便排出体外。结果表明，该材料可能是一种潜在的用于去除消化道内人体重金属铅的非注射材料。这种材料也可能是一种有用的排铅手段，尤其适用于非急性亚中毒症状。
