Tezcan Yilmaz, Surmeli Mustafa, Tastekin Didem, Koc Mehmet
N. E. U., Department of Radiation Oncology, Meram Faculty of Medicine, Konya, Turkey.
I. U., Department of Medical Oncology, Istanbul Faculty of Medicine, Istanbul, Turkey.
Arch Iran Med. 2015 Sep;18(9):606-7.
Cystoid macular edema is rarely observed secondary to paclitaxel treatment. A 55-year-old female patient was applied five cures of paclitaxel and carboplatin chemotherapy after being diagnosed with metastatic ovarian cancer. The patient had a normal bilateral vision prior to the chemotherapy treatments. After the fifth cure, the patient complained of bilateral vision loss, which was more severe in the left eye. Ophthalmologic examination revealed that right eye vision was 4/10 blurred without glasses and 7/10 blurred with glasses, left eye vision was 1/10 blurred without glasses and 4/10 blurred with glasses. Pathology was not detected during the biomicroscopic examination. Fundus examination of the patient revealed pigment epithelium irregularity, which was found to be less in the right eye, and it was found a decrease in foveal cavity. For fundus examination, the patient underwent fundus fluorescein angiography (FFA) and optical coherence tomography (OCT). FFA revealed fluorescein leakage and cystoid appearance particularly more apparent in the left eye. Thickening in the macula and cystoid space was observed particularly more in the left eye in the OCT measurement. In conclusion, we presented our case as a rarely observed cystoid macular edema secondary to paclitaxel treatment.
囊样黄斑水肿很少继发于紫杉醇治疗。一名55岁女性患者在被诊断为转移性卵巢癌后接受了5个疗程的紫杉醇和卡铂化疗。化疗前患者双眼视力正常。在第5个疗程后，患者抱怨双眼视力下降，左眼更严重。眼科检查显示，右眼裸眼视力为4/10模糊，戴眼镜后为7/10模糊，左眼裸眼视力为1/10模糊，戴眼镜后为4/10模糊。生物显微镜检查未发现病变。对患者进行眼底检查发现色素上皮不规则，右眼较轻，且发现黄斑中心凹变浅。为进行眼底检查，患者接受了眼底荧光血管造影（FFA）和光学相干断层扫描（OCT）。FFA显示荧光素渗漏和囊样外观，尤其在左眼更为明显。OCT测量显示，左眼黄斑增厚和囊样间隙更为明显。总之，我们报告了这例罕见的继发于紫杉醇治疗的囊样黄斑水肿病例。
