Millot P
Institut Pasteur, Paris, France.
Exp Clin Immunogenet. 1989;6(3):225-35.
In a Préalpe flock with endemic infection by Corynebacterium pseudotuberculosis, some sires seem to have transmitted some resistance traits not yet genetically defined. In sire progenies including offspring with and without abscess, abscesses occurred independently of the transmitted sire's OLA haplotype. However, in all considered offspring, some OLA antigens were positively or negatively associated with the delayed occurrence of abscess. The three antigens OLA-A4, A10, B6 were positively associated with delayed abscess and negatively with early abscess. Conversely, antigen OLA-A2 was negatively associated with delayed abscess and to a less extent positively with early abscess. When the three following groups of offspring without abscess (a), with late abscess (b) and with early abscess (c) were compared, frequencies of genes OLA-A4, A10, B6 on the one hand, OLA-A2 on the other hand, varied inversely, which shows that the OLA complex is linked to, at least, one locus from which the genes are implied in the delay of abscess formation (or precocity). Similarly, antigen OL-X5, loosely linked with the OLA complex, appeared to be positively associated with recurrent abscess and negatively with unique abscess. The observed associations were probably caused by linkage disequilibria between OLA (and OL) genes and genes influencing either the abscess delay or recurrence.
在一群感染了伪结核棒状杆菌的普雷阿尔普羊群中，一些种公羊似乎传递了一些尚未明确遗传定义的抗性特征。在包括有脓肿和无脓肿后代的种公羊后代中，脓肿的发生与所传递种公羊的OLA单倍型无关。然而，在所有考虑的后代中，一些OLA抗原与脓肿的延迟发生呈正相关或负相关。三种抗原OLA - A4、A10、B6与脓肿延迟呈正相关，与早期脓肿呈负相关。相反，抗原OLA - A2与脓肿延迟呈负相关，与早期脓肿呈较弱的正相关。当比较以下三组无脓肿后代（a）、晚期脓肿后代（b）和早期脓肿后代（c）时，一方面OLA - A4、A10、B6基因的频率，另一方面OLA - A2基因的频率呈相反变化，这表明OLA复合体至少与一个基因座相连，该基因座中的基因与脓肿形成延迟（或早熟）有关。同样，与OLA复合体松散连锁的抗原OL - X5似乎与复发性脓肿呈正相关，与单发脓肿呈负相关。观察到的关联可能是由OLA（和OL）基因与影响脓肿延迟或复发的基因之间的连锁不平衡引起的。
