Millot P, Chatelain J, Baille V, Cathala F
C R Acad Sci III. 1984;298(11):305-8.
The OLA genic frequencies were studied in both normal "Préalpe" Sheep and those affected with Scrapie. In the non-affected Sheep of contaminated flocks, frequencies were generally decreased, compared with frequencies of the same factors in sick Sheep or in non-infected controls. Three OLA-A genes significantly decreased; at this locus, results in "Préalpe" and "Ile-de-France" Sheep were inversed. This observation excludes OLA genes being involved in pathogeny or resistance to the disease, but suggests the existence of a linkage between the OLA loci and at least one resistance or susceptibility locus.
对正常的“前阿尔卑斯山”绵羊和感染羊瘙痒病的绵羊的OLA基因频率进行了研究。与患病绵羊或未感染对照中相同因素的频率相比，受污染羊群中未受影响的绵羊的频率通常会降低。三个OLA - A基因显著降低；在这个基因座上，“前阿尔卑斯山”绵羊和“法兰西岛”绵羊的结果相反。这一观察结果排除了OLA基因参与该病的发病机制或抗性，但表明OLA基因座与至少一个抗性或易感基因座之间存在连锁关系。
