Wu Chao-Chih, Yang Yuh-Cheng, Hsu Yun-Ting, Wu T-C, Hung Chien-Fu, Huang Jung-Tang, Chang Chih-Long
Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei City, Taiwan.
Department of Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan.
Oncotarget. 2015 Sep 29;6(29):26861-75. doi: 10.18632/oncotarget.4766.
Hyperthermic intraperitoneal chemotherapy is effective in treating various intra-abdominal malignancies. However, this therapeutic modality can only be performed during surgical operations and cannot be used repeatedly. We propose repeatedly noninvasive hyperthermia mediated by pegylated silica-core gold nanoshells (pSGNs) in vivo with external near-infrared (NIR) laser irradiation. This study demonstrated that repeated photothermal treatment can effectively eliminate intraperitoneal tumors in mouse ovarian cancer models without damage of normal tissues. By conjugating pSGNs with anti-human CD47 monoclonal antibody, a significant photoablative effect can be achieved using lower amount of pSGNs and shorter NIR laser irradiation. Conjugated pSGNs specifically targeted and bound to cancer cells inside the peritoneal cavity. Our results indicate the possibility of a noninvasive method of repeated hyperthermia and photoablative therapies using nanoparticles. This has substantial clinical potential in treating ovarian and other intraperitoneal cancers.
热腹腔内化疗在治疗各种腹腔内恶性肿瘤方面是有效的。然而，这种治疗方式只能在外科手术期间进行，且不能重复使用。我们提出通过聚乙二醇化的硅核金纳米壳（pSGNs）在体内进行反复无创热疗，并进行外部近红外（NIR）激光照射。本研究表明，反复光热治疗可有效消除小鼠卵巢癌模型中的腹腔肿瘤，而不会损伤正常组织。通过将pSGNs与抗人CD47单克隆抗体偶联，使用较少量的pSGNs和较短的近红外激光照射即可实现显著的光消融效果。偶联的pSGNs特异性地靶向并结合到腹腔内的癌细胞上。我们的结果表明了使用纳米颗粒进行反复热疗和光消融治疗的无创方法的可能性。这在治疗卵巢癌和其他腹腔内癌症方面具有巨大的临床潜力。
