Biscaglia Simone, Ceconi Claudio, Malagù Michele, Pavasini Rita, Ferrari Roberto
Department of Cardiology, University Hospital of Ferrara, Italy.
Department of Cardiology, University Hospital of Ferrara, Italy; LTTA Centre, University Hospital of Ferrara, Italy.
Int J Cardiol. 2016 Jun 15;213:28-32. doi: 10.1016/j.ijcard.2015.08.086. Epub 2015 Aug 8.
Uric acid is the final product of purine metabolism. Classically it is recognized as the cause of gouty arthritis and kidney stones. Western civilization has increased serum levels of uric acid which is no longer considered a benign plasma solute. It has been postulated and recently demonstrated that it can penetrate cell membrane and exerts damaging intracellular actions such as oxidation and inflammation. These observations have stimulated several epidemiological researches suggesting that hyperuricemia is linked or even provokes hypertension and coronary artery disease. In this review we summarize the current evidences regarding uric acid which contribute in the pathophysiology of coronary artery disease.
尿酸是嘌呤代谢的终产物。传统上，它被认为是痛风性关节炎和肾结石的病因。西方文明导致血清尿酸水平升高，尿酸不再被视为一种无害的血浆溶质。据推测且最近已得到证实，尿酸能够穿透细胞膜并在细胞内发挥氧化和炎症等破坏性作用。这些观察结果激发了多项流行病学研究，表明高尿酸血症与高血压和冠状动脉疾病有关，甚至可能引发这些疾病。在本综述中，我们总结了目前关于尿酸在冠状动脉疾病病理生理学中作用的证据。
