Zhang Hongshan, Geater Alan Frederick, Chongsuvivatwong Virasakdi, Zhu Guofu, Meng Yong, Duan Wenxiang, Pu Lijin
Department of Cardiac Function, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, Yunnan Province, China.
Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand.
Sci Rep. 2025 Apr 29;15(1):14990. doi: 10.1038/s41598-025-98213-7.
Brain-derived neurotrophic factor (BDNF) has been implicated in cardiovascular disease. However, the role of BDNF in coronary slow flow phenomenon (CSFP) remains unclear. This study explored the relationship between serum mature BDNF (mBDNF) levels and thrombolysis-in-myocardial-infarction frame count (TFC) as a measure of CSFP. Serum mBDNF was measured in 125 patients (mean age 60.2 years, 57% women) with suspected coronary artery disease before undergoing coronary angiography. Based on the corrected TFC, 77 patients were categorized as having CSFP and 48 normal coronary flow (NCF). The relationship of mTFC (mTFC) and CSFP with serum mBDNF was analysed using multivariable linear and logistic regression. mTFC ranged from 15.9 to 68.5 and mBDNF from 13.2 to 60.6 ng/mL. Serum mBDNF was inversely correlated with mTFC (Spearman rho - 0.327, P < 0.001) and reduced in CSFP (median 25.9 ng/mL IQR 20.6, 32.2 vs. 34.5 ng/mL IQR 27.4, 41.6, P < 0.001). Multivariable linear and logistic regression analyses indicated that log(mBDNF in ng/mL) has an inverse association with log(mTFC) (coefficient - 0.332,95% CI -0.513, -0.151; P < 0.001) and reduced odds of CSFP (odds ratio 0.188, 95% CI 0.062, 0.573; P = 0.003). This suggests that BDNF may serve as a biomarker of CSFP, and provides new insights into its pathophysiology.
脑源性神经营养因子（BDNF）与心血管疾病有关。然而，BDNF在冠状动脉慢血流现象（CSFP）中的作用仍不清楚。本研究探讨了血清成熟BDNF（mBDNF）水平与作为CSFP指标的心肌梗死溶栓帧数（TFC）之间的关系。在125例疑似冠状动脉疾病患者（平均年龄60.2岁，57%为女性）进行冠状动脉造影前测量血清mBDNF。根据校正后的TFC，77例患者被归类为患有CSFP，48例为正常冠状动脉血流（NCF）。使用多变量线性和逻辑回归分析mTFC（mTFC）和CSFP与血清mBDNF的关系。mTFC范围为15.9至68.5，mBDNF范围为13.2至60.6 ng/mL。血清mBDNF与mTFC呈负相关（Spearman秩相关系数-0.327，P<0.001），且在CSFP中降低（中位数25.9 ng/mL，四分位间距20.6，32.2 vs. 34.5 ng/mL，四分位间距27.4，41.6，P<0.001）。多变量线性和逻辑回归分析表明，log（mBDNF，单位为ng/mL）与log（mTFC）呈负相关（系数-0.332，95%置信区间-0.513，-0.151；P<0.001），且CSFP的发生几率降低（比值比0.188，95%置信区间0.062，0.573；P=0.003）。这表明BDNF可能作为CSFP的生物标志物，并为其病理生理学提供了新的见解。
