Andreadou Ioanna, Iliodromitis Efstathios K, Szabo Csaba, Papapetropoulos Andreas
Faculty of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 15771, Athens, Greece.
Basic Res Cardiol. 2015 Sep;110(5):510. doi: 10.1007/s00395-015-0510-9. Epub 2015 Aug 30.
Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H2S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.
在过去十年中，硫化氢已成为一种具有临床应用潜力的重要心脏保护分子。尽管已经提出了几种途径来介导硫化氢的有益作用，但一氧化氮/环磷酸鸟苷（NO/cGMP）轴已引起了广泛关注。最近的证据表明，依赖cGMP的蛋白激酶既可以位于硫化氢的下游，也可以位于其上游。本文综述了关于这一主题的现有文献，并整合了近期研究的数据，以提出一个统一的模型。
