Xu Xin, Shan Bin, Liao Cai-Hu, Xie Jian-Hua, Wen Ping-Wei, Shi Jia-Yi
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China.
College of Yingdong Food Science and Engineering, Shaoguan University, Shaoguan 512005, China.
Int J Biol Macromol. 2015 Nov;81:538-43. doi: 10.1016/j.ijbiomac.2015.08.049. Epub 2015 Aug 28.
A water-soluble polysaccharide (MCP) was isolated from the fruits of Momordica charantia L., and the hypoglycemic effects of MCP were investigated in both normal healthy and alloxan-induced diabetic mice. MCP was orally administered once a day after 3 days of alloxan-induction at 100, 200 and 300mg/kg body weight for 28 day. Results showed that fasting blood glucose level (BGL) was significantly decreased, whereas the glucose tolerance was marked improvement in alloxan-induced diabetic mice, and loss in body weight was also prevented in diabetic mice compared to the diabetic control group. The dosage of 300mg/kg body weight exhibited the best effects. In addition, MCP did not exhibit any toxic symptoms in the limited toxicity evaluation in mice. The results suggest that MCP possess significantly dose-dependent anti-diabetic activity on alloxan-induced diabetic mice. Hence, MCP can be incorporated as a supplement in health-care food, drugs and/or combined with other hypoglycemic drugs.
从苦瓜果实中分离出一种水溶性多糖（MCP），并在正常健康小鼠和四氧嘧啶诱导的糖尿病小鼠中研究了MCP的降血糖作用。在四氧嘧啶诱导3天后，以100、200和300mg/kg体重的剂量每天口服一次MCP，持续28天。结果表明，四氧嘧啶诱导的糖尿病小鼠空腹血糖水平（BGL）显著降低，葡萄糖耐量明显改善，与糖尿病对照组相比，糖尿病小鼠的体重减轻也得到了预防。300mg/kg体重的剂量表现出最佳效果。此外，在小鼠的有限毒性评估中，MCP未表现出任何毒性症状。结果表明，MCP对四氧嘧啶诱导的糖尿病小鼠具有显著的剂量依赖性抗糖尿病活性。因此，MCP可作为保健品、药物中的补充剂和/或与其他降糖药物联合使用。
