Singh N, Gupta M, Sirohi P
Environmental Endocrinology and Bio-medical Research Unit, Department of Zoology, Meerut College, Meerut 250 003, India.
J Environ Biol. 2008 Jan;29(1):101-6.
Alcoholic extract of whole fruit of Momordica charantia was prepared. Adult healthy albino rats were divided into four groups and received a dose of 6 mg/l00 gm. body weight of alloxan monohydrate. Animals of group I served as diabetic control group. The animals of II, III, and IV groups received 25 mg, 50 mg and 75 mg doses of the extract respectively for different durations. 75 mg dose showed increase in body weight. All doses of alcoholic extract of M. charantia were able to decrease the blood sugar level significantly. Extract feeding showed definite improvement in the islets of Langerhans. No toxic effect was observed in the liver The significant features of the study have been blood glucose once lowered by the treatment with M. charantia fruit extract remained static even after discontinuation of drug for 15 days. Blood sugar never fell below normal values even with a high dose, in pancreatic islets, beta cells showed definite improvement.
制备了苦瓜全果的酒精提取物。将成年健康白化大鼠分为四组，给予单水合四氧嘧啶剂量为6毫克/100克体重。第一组动物作为糖尿病对照组。第二、三、四组动物分别接受25毫克、50毫克和75毫克剂量的提取物，持续不同时间。75毫克剂量组体重增加。苦瓜酒精提取物的所有剂量均能显著降低血糖水平。喂食提取物显示胰岛有明显改善。在肝脏中未观察到毒性作用。该研究的显著特点是，用苦瓜果实提取物治疗后血糖一旦降低，即使停药15天仍保持稳定。即使高剂量给药，血糖也从未降至正常值以下，胰腺胰岛中的β细胞有明显改善。
