儿童哮喘的管理与环境触发因素

Childhood Asthma Management and Environmental Triggers.

作者信息

Hollenbach Jessica P, Cloutier Michelle M

机构信息

Department of Pediatrics, Asthma Center, The Children's Center for Community Research, CT Children's Medical Center, University of Connecticut School of Medicine, 282 Washington Street, Hartford, CT 06106, USA.

Department of Pediatrics, Asthma Center, The Children's Center for Community Research, Connecticut Children's Medical Center, University of Connecticut Health Center, 282 Washington Street, Hartford, CT 06106, USA.

出版信息

Pediatr Clin North Am. 2015 Oct;62(5):1199-214. doi: 10.1016/j.pcl.2015.05.011. Epub 2015 Jul 26.

DOI:10.1016/j.pcl.2015.05.011

PMID:26318947

Abstract

Asthma is the most common chronic disease among children. It cannot be prevented but can be controlled. Industrialized countries experience high lifetime asthma prevalence that has increased over recent decades. Asthma has a complex interplay of genetic and environmental triggers. Studies have revealed complex interactions of lung structure and function genes with environmental exposures such as environmental tobacco smoke and vitamin D. Home environmental strategies can reduce asthma morbidity in children but should be tailored to specific allergens. Coupled with education and severity-specific asthma therapy, tailored interventions may be the most effective strategy to manage childhood asthma.

摘要

哮喘是儿童中最常见的慢性疾病。它无法预防，但可以得到控制。工业化国家的哮喘终生患病率很高，且在近几十年有所上升。哮喘是由遗传和环境触发因素复杂相互作用导致的。研究揭示了肺结构和功能基因与环境暴露（如环境烟草烟雾和维生素D）之间的复杂相互作用。家庭环境策略可以降低儿童哮喘的发病率，但应针对特定过敏原进行调整。结合教育和针对严重程度的哮喘治疗，量身定制的干预措施可能是管理儿童哮喘最有效的策略。