Abdelnaseer Maged, Elfayomi Nervana, Esmail Eman H, Kamal Manal M, Hamdy Ahmed, Samie Rasha M Abdel, Elsawy Enji
Neurology Department, Cairo University, 49 Misr Hilwan Elzraai Street, Maadi, Cairo, 2218, Egypt.
Chemical and Clinical Pathology Department, Cairo University, Cairo, Egypt.
Neurol Sci. 2016 Jan;37(1):117-122. doi: 10.1007/s10072-015-2358-z. Epub 2015 Aug 30.
Atherosclerosis causes significant morbidity and mortality. Carotid intima media thickness (IMT) predicts future ischaemic strok e incidence. Matrix metalloproteinases (MMPs) play a considerable role in atherosclerosis and hold therapeutic promise as well. To investigate the relationship between serum level of matrix metalloproteinase-9 (MMP-9) and common carotid artery intima media thickness (CCA-IMT) in patients with ischaemic stroke and asymptomatic subjects. Thirty patients with a previous ischaemic stroke and 30 asymptomatic volunteers were recruited. Assessment of vascular risk factors, serum level of MMP-9 and CCA-IMT on both sides was performed. The IMT of both CCAs correlated positively with the serum MMP-9 level in asymptomatic subjects (p = 0.000), even after adjustment for other risk factors. In the patients group, this positive correlation was significant for the right but not for the left CCA (right CCA: p = 0.023, left CCA: p = 0.0284). Fasting blood sugar correlated positively with serum levels of MMP-9 in asymptomatic subjects (p = 0.005) but did not correlate positively in patients. There was no significant correlation between MMP-9 and age or other investigated laboratory risk factors in either the patient or asymptomatic groups. MMP-9 is positively correlated with CCA-IMT both in stroke patients and asymptomatic subjects. This may indicate that MMP-9 is a possible therapeutic target for stroke prevention.
动脉粥样硬化会导致严重的发病和死亡。颈动脉内膜中层厚度（IMT）可预测未来缺血性卒中的发生率。基质金属蛋白酶（MMPs）在动脉粥样硬化中起重要作用，也具有治疗前景。为了研究缺血性卒中患者和无症状受试者血清基质金属蛋白酶-9（MMP-9）水平与颈总动脉内膜中层厚度（CCA-IMT）之间的关系。招募了30例既往有缺血性卒中的患者和30名无症状志愿者。对血管危险因素、血清MMP-9水平和双侧CCA-IMT进行评估。在无症状受试者中，即使在调整其他危险因素后，双侧CCA的IMT与血清MMP-9水平呈正相关（p = 0.000）。在患者组中，这种正相关在右侧CCA显著，而在左侧CCA不显著（右侧CCA：p = 0.023，左侧CCA：p = 0.0284）。空腹血糖在无症状受试者中与血清MMP-9水平呈正相关（p = 0.005），但在患者中无正相关。在患者组或无症状组中，MMP-9与年龄或其他研究的实验室危险因素之间均无显著相关性。MMP-9在卒中患者和无症状受试者中均与CCA-IMT呈正相关。这可能表明MMP-9是预防卒中的一个可能的治疗靶点。
