Department of Neurology and Epileptology, Centre of Postgraduate Medical Education, 231 Czerniakowska st, 00-416 Warsaw, Poland.
Department of General Surgery and Clinical Nutrition, Centre of Postgraduate Medical Education, 231 Czerniakowska st, 00-416 Warsaw, Poland.
Nutr Metab Cardiovasc Dis. 2021 Feb 8;31(2):489-497. doi: 10.1016/j.numecd.2020.09.019. Epub 2020 Oct 27.
Nutrition regimen in parenteral nutrition (PN) patients allows for a control of diet components. This may affect the process of lipid deposition in the vascular wall and change the risk of atherosclerosis. This study aims to examine the effect of long-term PN in adults on carotid intima-media thickness.
Thirty long-term PN patients (15 men and 15 women, mean age 64.7 ± 8.5 years) and thirty healthy volunteers (HV) (15 men and 15 women, mean age 64.9 ± 8.77 years) entered the study. Total amino acid and lipid formulation intake as well as duration of PN were calculated for PN patients. The common carotid artery intima-media thickness (CCA IMT) was examined in both groups. A lower CCA IMT (right/left mean: PN - 776 ± 121 vs HV - 848 ± 121 μm, p < 0.05; right/left maximum CCA IMT: PN - 935 ± 139 vs HV - 1024 ± 135 μm, p < 0.05) in PN patients was observed. A lower serum level of total (PN - 131.43 ± 43.12 vs HV - 209.2 ± 48.01 mg/dl, p < 0.05) and HDL (PN- 44.16 ± 12.45 vs HV - 72.57 ± 25.04 mg/dl, p < 0.05) cholesterol was reported in the PN patients. A correlation between patients' age and CCA IMT was observed in the control group, but not in the PN patients (right/left mean CCA IMT - PN: r = 0.48, p-0.007 vs HV: p-0.073; right/left maximum CCA IMT - PN: r = 0.48, p-0.008, vs HV: p-0.073).
Long term PN in adults is associated with lower CCA IMT. Long-term PN patients are a unique group in which carotid intima-media thickness does not correlate with the age.
肠外营养（PN）患者的营养方案可控制饮食成分。这可能会影响血管壁内脂质沉积的过程，并改变动脉粥样硬化的风险。本研究旨在探讨成人长期 PN 对颈动脉内膜中层厚度的影响。
30 例长期 PN 患者（15 名男性和 15 名女性，平均年龄 64.7±8.5 岁）和 30 名健康志愿者（HV）（15 名男性和 15 名女性，平均年龄 64.9±8.77 岁）纳入研究。计算了 PN 患者的总氨基酸和脂质配方摄入量以及 PN 持续时间。在两组中均检查了颈总动脉内膜中层厚度（CCA IMT）。PN 患者的 CCA IMT 较低（右侧/左侧平均：PN-776±121 与 HV-848±121μm，p<0.05；右侧/左侧最大 CCA IMT：PN-935±139 与 HV-1024±135μm，p<0.05）。PN 患者的总胆固醇（PN-131.43±43.12 与 HV-209.2±48.01mg/dl，p<0.05）和高密度脂蛋白（HDL）（PN-44.16±12.45 与 HV-72.57±25.04mg/dl，p<0.05）血清水平较低。在对照组中观察到患者年龄与 CCA IMT 之间存在相关性，但在 PN 患者中则没有（右侧/左侧平均 CCA IMT-PN：r=0.48，p-0.007 与 HV：p-0.073；右侧/左侧最大 CCA IMT-PN：r=0.48，p-0.008 与 HV：p-0.073）。
成人长期 PN 与较低的 CCA IMT 相关。长期 PN 患者是一个独特的群体，其颈动脉内膜中层厚度与年龄无关。
