Gonçalves Guilherme, Frade João, Nunes Carla, Mesquita João Rodrigo, Nascimento Maria São José
Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto Rua de Jorge Viterbo Ferreira, no. 228, Porto 4050-313, Portugal; Unit for Multidisciplinary Biomedical Research (UMIB) Rua de Jorge Viterbo Ferreira, no 228, Porto 4050-313, Portugal.
School of Health Sciences, Polytechnic Institute of Leiria Campus 2 - Morro do Lena - Alto do Vieiro, Apartado 4137, Leiria 2411-901, Portugal; National School of Public Health, Universidade Nova de Lisboa Avenida Padre Cruz, Lisboa 1600-560, Portugal.
Vaccine. 2015 Sep 22;33(39):5057-63. doi: 10.1016/j.vaccine.2015.08.057. Epub 2015 Aug 28.
In populations vaccinated with two doses of combined measles-mumps-rubella vaccine (MMR), the serum levels of antibodies against measles depend on the vaccination schedule, time elapsed from the last dose and the area-specific epidemiological situation. Variables measuring "schedule" are age at first and second doses of MMR and intervals derived from that. Changes in vaccination schedules have been made in Portugal. The specific objectives of this study were to measure the association between those potential determinants and the concentration of measles-specific IgG antibodies, after the second dose of MMR. Convenience samples of three Portuguese birth cohorts were selected for this study (41, 66 and 60 born, respectively, in 2001-2003, 1990-1993 and 1994-1995). Geometric mean concentrations (GMC) for measles IgG were, respectively, 934, 251 and 144mIU/ml; p<0.001). Anti-measles-IgG serum concentration decreased with time since last vaccination (waning immunity) and was not influenced by any other component of vaccination schedule, namely age at vaccination with the second dose of MMR. Waning levels of measles antibodies have been observed elsewhere but not as fast as it was observed in Portuguese birth cohorts in this study. Changes in the vaccination schedules might have to be considered in the future.
在接种两剂麻疹-腮腺炎-风疹联合疫苗（MMR）的人群中，抗麻疹抗体的血清水平取决于疫苗接种程序、自最后一剂疫苗接种后经过的时间以及特定地区的流行病学情况。衡量“接种程序”的变量包括首次和第二次接种MMR疫苗时的年龄以及由此得出的间隔时间。葡萄牙已对疫苗接种程序进行了调整。本研究的具体目标是在接种第二剂MMR疫苗后，测量这些潜在决定因素与麻疹特异性IgG抗体浓度之间的关联。本研究选取了三个葡萄牙出生队列的便利样本（分别为2001 - 2003年、1990 - 1993年和1994 - 1995年出生的41名、66名和60名儿童）。麻疹IgG的几何平均浓度（GMC）分别为934、251和144mIU/ml；p<0.001）。抗麻疹IgG血清浓度随自上次接种疫苗后的时间推移而下降（免疫力减弱），且不受疫苗接种程序的任何其他因素影响，即第二次接种MMR疫苗时的年龄。在其他地方也观察到了麻疹抗体水平的下降，但不如本研究中在葡萄牙出生队列中观察到的下降速度快。未来可能需要考虑疫苗接种程序的调整。
