Department of Virology, School of Public Health, Tehran University of Medical Sciences, Poursina Ave, Qods St, Enqelab Sq, Tehran, Iran.
National Measles and Rubella Lab of Iran, Tehran, Iran.
BMC Infect Dis. 2024 Jul 12;24(1):696. doi: 10.1186/s12879-024-09593-6.
The seroprevalence of antibodies against measles, mumps, and rubella (MMR) was evaluated 17 years following a mass vaccination campaign in individuals aged 2 to 22 years who had received routine immunization but were not eligible for an extended immunization program.
Samples were acquired from Iran's National Measles Laboratory (NML), with individuals showing positive IgM results excluded. Out of the samples collected in 2020, a random selection of 290 serum samples was chosen, representing individuals between the ages of 2 and 22 years from diverse regions in the country. These samples were subjected to analysis using an enzyme-linked immunosorbent assay (ELISA) to quantify specific IgG antibodies against MMR.
The seroprevalence rates of antibodies for measles, mumps, and rubella were determined to be 76.2%, 89.3%, and 76.9%, respectively. Younger age groups exhibited higher seropositivity rates for measles and mumps, whereas the 7- to 11-year-old group demonstrated the highest seropositivity rate for rubella. A reduction in antibody status was observed from younger to older age groups, particularly those aged 17-22.
The study unveiled suboptimal antibody levels for measles and rubella, highlighting the necessity for further investigation and potential adjustments to future vaccination strategies. Moreover, the decline in antibody status post-vaccination can accumulate in seronegative individuals over time, elevating the risk of outbreaks.
在大规模疫苗接种运动 17 年后，对接受常规免疫但不符合扩大免疫计划的 2 至 22 岁人群进行了麻疹、腮腺炎和风疹（MMR）抗体的血清阳性率评估。
从伊朗国家麻疹实验室（NML）获取样本，排除 IgM 结果阳性的个体。在 2020 年采集的样本中，随机选择了 290 份血清样本，代表来自该国不同地区 2 至 22 岁的个体。这些样本通过酶联免疫吸附试验（ELISA）进行分析，以定量 MMR 特异性 IgG 抗体。
麻疹、腮腺炎和风疹抗体的血清阳性率分别为 76.2%、89.3%和 76.9%。年龄较小的群体对麻疹和腮腺炎的血清阳性率较高，而 7-11 岁年龄组对风疹的血清阳性率最高。抗体状态从年轻到老年逐渐下降，特别是 17-22 岁年龄组。
研究揭示了麻疹和风疹的抗体水平不理想，这突出表明需要进一步调查并可能调整未来的疫苗接种策略。此外，接种疫苗后抗体状态的下降会随着时间的推移在血清阴性个体中累积，增加暴发的风险。
