Zhou Xinyue, Meng Yuanguang
Department of Obstetrics and Gynecology, the General Hospital of PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Arch Gynecol Obstet. 2016 Apr;293(4):871-7. doi: 10.1007/s00404-015-3852-5. Epub 2015 Aug 29.
The aim of this study was to evaluate the association between serum folate level and cervical cancer.
PubMed, Medline, Springer, Elsevier Science Direct, Cochrane Library and Google scholar were searched for relevant trials. Rev.Man5.1 and Stata 11.0 software were applied for this meta-analysis. Odds Ratio (OR) and 95 % confidence intervals (95 % CI) were collected and calculated in a fixed-effects model or a random-effects model when appropriate. Subgroup analysis was performed by sample size, participant's geographical location and definition of deficient serum folate level.
A total of 6 case-control studies including 2383 participants were included in the meta-analysis. The overall meta-analysis showed that there were significant differences between cases and controls, suggesting that deficient serum folate level was associated with the increased risk of cervical cancer. After stratification subgroup analysis, significant difference was also found in subgroup with sample size <500 as well as in Asian population, but not in subgroup with sample size ≥500, American populations as well as different definition of deficient serum folate level (<6.4 ng/ml or others).
Based on our meta-analysis, deficiency of serum folate level was associated with the increased risk of cervical cancer among Asian populations.
本研究旨在评估血清叶酸水平与宫颈癌之间的关联。
检索了PubMed、Medline、Springer、Elsevier Science Direct、Cochrane图书馆和谷歌学术等数据库中的相关试验。应用Rev.Man5.1和Stata 11.0软件进行该荟萃分析。在适当情况下，采用固定效应模型或随机效应模型收集并计算比值比（OR）和95%置信区间（95%CI）。按样本量、参与者地理位置和血清叶酸缺乏水平的定义进行亚组分析。
该荟萃分析共纳入6项病例对照研究，包括2383名参与者。总体荟萃分析表明，病例组与对照组之间存在显著差异，提示血清叶酸水平缺乏与宫颈癌风险增加相关。分层亚组分析后，样本量<500的亚组以及亚洲人群中也发现了显著差异，但样本量≥500的亚组、美国人群以及血清叶酸缺乏水平的不同定义（<6.4 ng/ml或其他）中未发现显著差异。
基于我们的荟萃分析，血清叶酸水平缺乏与亚洲人群宫颈癌风险增加相关。
