Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Department of Clinical Medicine, The Nanshan College of Guangzhou Medical University, Guangzhou, 511436, China.
BMC Infect Dis. 2023 Jan 23;23(1):48. doi: 10.1186/s12879-022-07950-x.
Increased folic acid has been found to be latently protective against gynecological infection, including several kinds of vaginosis. In this study, we laid emphasis on whether RBC (Red Blood Cell) folate was associated with the infectious ratio of Trichomonas vaginalis, a kind of anaerobic parasitic protozoan.
We set RBC folate as the exposure variable and Trichomonas vaginalis as the outcome variable. Other subsidiary variables were regarded as covariates that may work as potential effect modifiers. The cross-sectional study was conducted with two merged waves of the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004, and a sample of 1274 eligible women (1212 negative and 62 positive in Trichomonas vaginalis infection) was integrated for the exploration of the association between RBC folate and Trichomonas vaginalis infection. Multivariate regression analyses, subgroup analyses, and subsequent smooth curve fittings were conducted to estimate the relationship between RBC folate and Trichomonas vaginalis in women.
In the multivariable logistic regression analyses, a negative association was observed between stratified RBC folate status and Trichomonas vaginalis infection with all confounders adjusted. Referencing the lowest RBC folate concentration quartile, the higher concentration quartiles reported a relatively lower infection ratio, while there was a weak correlation between total RBC folate concentration and T. vaginalis (Trichomonas vaginalis) infection. In subgroup analyses stratified by BMI and age, this association was only found significant in high age and BMI groups.
The cross-sectional study indicated a negative association between RBC folic acid and Trichomonas vaginalis infection, and latent effects of BMI and age on the association were also found.
已发现增加叶酸含量可潜在预防妇科感染，包括多种阴道病。在这项研究中，我们重点关注红细胞叶酸（RBC folate）是否与阴道毛滴虫感染率有关，阴道毛滴虫是一种厌氧寄生原生动物。
我们将 RBC 叶酸作为暴露变量，将阴道毛滴虫作为结果变量。其他辅助变量被视为可能作为潜在效应修饰剂的协变量。本横断面研究结合了 2001 年至 2004 年两次国家健康和营养检查调查（NHANES）的数据，纳入了 1274 名符合条件的女性（1212 名阴道毛滴虫感染阴性，62 名阳性），以探讨 RBC 叶酸与阴道毛滴虫感染之间的关系。进行多变量回归分析、亚组分析和后续的平滑曲线拟合，以估计 RBC 叶酸与女性阴道毛滴虫感染之间的关系。
在多变量逻辑回归分析中，在调整了所有混杂因素后，分层 RBC 叶酸状态与阴道毛滴虫感染呈负相关。与 RBC 叶酸最低浓度四分位数相比，较高浓度四分位数报告的感染率相对较低，而总 RBC 叶酸浓度与阴道毛滴虫感染之间存在弱相关性。在按 BMI 和年龄分层的亚组分析中，仅在高年龄和 BMI 组中发现了这种相关性。
这项横断面研究表明，RBC 叶酸与阴道毛滴虫感染呈负相关，并且 BMI 和年龄对这种相关性的潜在影响也被发现。
