Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
Biosens Bioelectron. 2016 Jan 15;75:273-84. doi: 10.1016/j.bios.2015.08.037. Epub 2015 Aug 20.
Smartphone has been widely integrated with sensors, such as test strips, sensor chips, and hand-held detectors, for biochemical detections due to its portability and ubiquitous availability. Utilizing built-in function modules, smartphone is often employed as controller, analyzer, and displayer for rapid, real-time, and point-of-care monitoring, which can significantly simplify design and reduce cost of the detecting systems. This paper presents a review of biosensors and bioelectronics on smartphone for portable biochemical detections. The biosensors and bioelectronics based on smartphone can mainly be classified into biosensors using optics, surface plasmon resonance, electrochemistry, and near-field communication. The developments of these biosensors and bioelectronics on smartphone are reviewed along with typical biochemical detecting cases. Sensor strategies, detector attachments, and coupling methods are highlighted to show designs of the compact, lightweight, and low-cost sensor systems. The performances and advantages of these designs are introduced with their applications in healthcare diagnosis, environment monitoring, and food evaluation. With advances in micro-manufacture, sensor technology, and miniaturized electronics, biosensor and bioelectronic devices on smartphone can be used to perform biochemical detections as common and convenient as electronic tag readout in foreseeable future.
智能手机由于其便携性和无处不在的可用性，已经广泛集成了各种传感器，如测试条、传感器芯片和手持式探测器，用于生化检测。利用内置的功能模块，智能手机通常被用作快速、实时和即时检测的控制器、分析仪和显示器，这可以显著简化检测系统的设计并降低成本。本文综述了智能手机上用于便携式生化检测的生物传感器和生物电子学。基于智能手机的生物传感器和生物电子学主要可以分为基于光学、表面等离子体共振、电化学和近场通信的生物传感器。本文综述了这些基于智能手机的生物传感器和生物电子学的发展情况，并介绍了典型的生化检测案例。重点介绍了传感器策略、检测器附件和耦合方法，以展示紧凑、轻巧和低成本传感器系统的设计。介绍了这些设计的性能和优点，并介绍了它们在医疗诊断、环境监测和食品评估中的应用。随着微制造、传感器技术和小型化电子技术的进步，生物传感器和生物电子设备在智能手机上的应用将变得像电子标签读取一样常见和方便，可以预见，在不久的将来，它们将用于生化检测。
