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[粪便移植:未来的疗法?]

[Fecal transplantation the future therapy?].

作者信息

Rebizak Ewelina, Sierant Katarzyna, Łabuzek Krzysztof, Okopień Bogusław

机构信息

Department of Internal Diseases and Clinical Pharmacology, Silesian.

出版信息

Pol Merkur Lekarski. 2015 Aug;39(230):73-6.

Abstract

Intestinal bacteria play an important role in human physiology, taking part in the metabolism, absorption of nutrients and regulation of the immune system. In many illnesses the bacterial imbalance in the digestive tract occurs, and fecal transplantation is one method that allows you to restore the balance. The essence of the described method is to replace the pathogenesis, abnormal bacterial flora with the flora occurring in normal healthy individuals. So far, the main use of the method described in the article is resistant to antibiotics Clostridium difficile infection, which gives you a chance to avoid total colectomy. The article presents an accurate description of the same procedure to prepare the material, the selection of donor, recipient preparation and diseases, such as inflammatory bowel diseases, irritable bowel syndrome, diabetes and obesity, in which this method of treatment is currently practised.

摘要

肠道细菌在人体生理机能中发挥着重要作用,参与新陈代谢、营养吸收以及免疫系统调节。在许多疾病中,消化道会出现细菌失衡的情况,而粪便移植是一种能够恢复平衡的方法。所述方法的本质是用正常健康个体体内的菌群替代致病的、异常的细菌菌群。到目前为止,本文所述方法的主要用途是治疗对抗生素耐药的艰难梭菌感染,这使人们有机会避免进行全结肠切除术。本文准确描述了该治疗方法的相同步骤,包括材料准备、供体选择、受体准备以及目前正在采用这种治疗方法的疾病,如炎症性肠病、肠易激综合征、糖尿病和肥胖症。

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