Chiou Yuan-Yow, Lin Ching-Yuang, Chen Mei-Ju, Chiou Yee-Hsuan, Wang Yi-Fan, Wang Hsin-Hui, Tain You-Lin, Chou Hsin-Hsu
Department of Pediatrics, Institute of Clinical Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan.
Children's Hospital of China Medical University, Taichung, Taiwan.
J Formos Med Assoc. 2016 Sep;115(9):752-63. doi: 10.1016/j.jfma.2015.07.019. Epub 2015 Aug 29.
BACKGROUND/PURPOSE: This study aims to examine the characteristics of Taiwanese children with chronic kidney disease (CKD) and delineate the factors that lead to disease progression in this population.
We reviewed the records of the Taiwan Pediatric Renal Collaborative Study, a multicenter database of Taiwanese children with CKD. Multivariate regression analysis was used to identify the main factors associated with disease progression.
A total of 382 children aged 1-18 years were included in the study (median age was 10.6 years; interquartile range: 6.4-13.8). There were 197 males (51.6%) and 185 females. CKD Stage 1 was diagnosed in 159 children (41.6%), Stage 2 in 160 (41.9%), Stage 3 in 51 (13.4%), and Stage 4 in 12 (3.1%). Fifty-six children (14.7%) experienced CKD progression. A multivariate analysis for all patients indicated that the risk for disease progression was increased in children with CKD secondary to a structural abnormality, genetic disease, anemia, elevated diastolic blood pressure, or elevated blood urea nitrogen. Compared with children with Stage 1 CKD, those with Stage 2 and Stage 4 CKD had decreased risk for CKD progression in this short-term cohort follow-up.
CKD etiology affects disease progression. Careful monitoring and treatment of anemia and elevated blood pressure in children with CKD may slow disease progression.
背景/目的：本研究旨在探讨台湾慢性肾脏病（CKD）儿童的特征，并确定导致该人群疾病进展的因素。
我们回顾了台湾儿童肾脏协作研究的记录，这是一个关于台湾CKD儿童的多中心数据库。采用多变量回归分析来确定与疾病进展相关的主要因素。
共有382名1至18岁的儿童纳入研究（中位年龄为10.6岁；四分位间距：6.4 - 13.8）。其中男性197名（51.6%），女性185名。159名儿童（41.6%）被诊断为CKD 1期，160名（41.9%）为2期，51名（13.4%）为3期，12名（3.1%）为4期。56名儿童（14.7%）经历了CKD进展。对所有患者的多变量分析表明，继发于结构异常、遗传疾病、贫血、舒张压升高或血尿素氮升高的CKD儿童疾病进展风险增加。在这个短期队列随访中，与CKD 1期儿童相比，2期和4期CKD儿童的CKD进展风险降低。
CKD病因影响疾病进展。对CKD儿童的贫血和血压升高进行仔细监测和治疗可能会减缓疾病进展。
