Bachour Dala-Maria, Chahin Emil, Al-Fahoum Sahar
Department of Clinical Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria E-mail :
Asian Pac J Cancer Prev. 2015;16(14):5967-70. doi: 10.7314/apjcp.2015.16.14.5967.
The prevalence of prostate cancer is considered high in many countries, and screening tests are very important in order to detect prostate cancer in its early stages; however false positivity with these screening tests means that a lot of patients undergo unnecessary biopsy, which is an invasive procedure, for the confirmatory test. The purpose of this study was to estimate the frequency of unnecessary biopsy cases in patients referred for prostate biopsy in one of the most important and overload cancer centers in Syria.
Retrospective data for a period of four years between January 2009 and December 2012 were collected in Al- Bayrouni University Medical hospital in Damascus, Syria. The patients from whom data were collected were referred to our histopathological department because of elevated prostate specific antigen (PSA) serum or an abnormal digital rectal examination (DRE). All patients underwent prostatic TRUS-guided biopsies. Diagnosis of prostate cancer (PCa) or benign prostatic hyperplasia (BPH) was based on histopathological examination and prostate cancers cases were graded and scored according to the Gleason score system.
For the 406 patients referred to biopsy, the mean±SD age was 58.4 ±23.3 years. The mean ± SD PSA level was 49.2±21.5 ng/ ml. Of the total we found 237 patients diagnosed with PCa (58. 4%), 166 patients with BPH (40.9%) and 3 cases were unable to be diagnosed (0.7%) because of biopsy collection errors.
Our study shows that a high percentage of patients are undergoing unnecessary biopsy, which suggests that the performed screening tests had a high level of false positive and may need re-evaluation.
在许多国家，前列腺癌的患病率被认为较高，为了在早期阶段检测出前列腺癌，筛查测试非常重要；然而，这些筛查测试的假阳性意味着许多患者接受了不必要的活检，而活检是一种侵入性操作，用于确诊。本研究的目的是估计在叙利亚最重要且负担过重的癌症中心之一，接受前列腺活检的患者中不必要活检病例的发生率。
收集了叙利亚大马士革的拜鲁尼大学医学医院2009年1月至2012年12月期间四年的回顾性数据。收集数据的患者因前列腺特异性抗原（PSA）血清升高或直肠指检（DRE）异常而被转诊至我们的组织病理学科室。所有患者均接受了经直肠超声引导下的前列腺活检。前列腺癌（PCa）或良性前列腺增生（BPH）的诊断基于组织病理学检查，前列腺癌病例根据Gleason评分系统进行分级和评分。
对于406例接受活检的患者，平均±标准差年龄为58.4±23.3岁。平均±标准差PSA水平为49.2±21.5 ng/ml。在所有患者中，我们发现237例被诊断为PCa（58.4%），166例为BPH（40.9%），3例因活检采集错误无法诊断（0.7%）。
我们的研究表明，高比例的患者正在接受不必要的活检，这表明所进行的筛查测试假阳性率较高，可能需要重新评估。
