替米沙坦/氢氯噻嗪所致肝毒性。 - Suppr

Telmisartan/hydrochlorothiazide-induced hepatotoxicity.

作者信息

Lorena Marco, Autolitano Aldo, Natale Giovanni, Uberti Federica, Vitali Fabrizio, Schiantarelli Camillo, Liberato Nicola Lucio

机构信息

Internal Medicine, Azienda Ospedaliera della Provincia di Pavia, Ospedale Civile "Asilo Vittoria", Mortara (PV), Italy.

Internal Medicine, Azienda Ospedaliera della Provincia di Pavia, Ospedale Civile "Carlo Mira", Casorate Primo (PV), Italy.

出版信息

Arch Med Sci. 2015 Aug 12;11(4):893-4. doi: 10.5114/aoms.2015.53311. Epub 2015 Aug 11.

DOI:10.5114/aoms.2015.53311

PMID:26322103

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4548043/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14af/4548043/2216a17ad499/AMS-11-25591-g001.jpg

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Telmisartan/hydrochlorothiazide-induced hepatotoxicity.替米沙坦/氢氯噻嗪所致肝毒性。

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Multiple-dose pharmacokinetics of telmisartan and of hydrochlorothiazide following concurrent administration in healthy subjects.替米沙坦与氢氯噻嗪在健康受试者中联合给药后的多剂量药代动力学。

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Comparison of telmisartan/amlodipine and telmisartan/hydrochlorothiazide in the treatment of Japanese patients with uncontrolled hypertension: the TAT-Kobe study.替米沙坦/氨氯地平和替米沙坦/氢氯噻嗪治疗日本血压控制不佳患者的比较：TAT-神户研究

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Effects of the angiotensin II receptor blockers telmisartan versus valsartan in combination with hydrochlorothiazide: a large, confirmatory trial.血管紧张素II受体阻滞剂替米沙坦与缬沙坦联合氢氯噻嗪的疗效比较：一项大型验证性试验。

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Treatment of hypertension: postmarketing surveillance study results of telmisartan monotherapy, fixed dose combination of telmisartan + hydrochlorothiazide/amlodipine.高血压的治疗：替米沙坦单药治疗、替米沙坦+氢氯噻嗪/氨氯地平固定剂量联合治疗的上市后监测研究结果

J Indian Med Assoc. 2009 Oct;107(10):730-3.

Telmisartan plus hydrochlorothiazide versus telmisartan or hydrochlorothiazide monotherapy in patients with mild to moderate hypertension: a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial.替米沙坦联合氢氯噻嗪与替米沙坦或氢氯噻嗪单药治疗轻至中度高血压患者：一项多中心、随机、双盲、安慰剂对照、平行组试验。

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Fixed-dose telmisartan/hydrochlorothiazide in comparison with losartan/hydrochlorothiazide in decreasing serum hepatocyte growth factor and improving endothelial dysfunction in hypertensive patients.固定剂量替米沙坦/氢氯噻嗪与氯沙坦/氢氯噻嗪相比，在降低高血压患者血清肝细胞生长因子及改善内皮功能障碍方面的研究

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本文引用的文献

Acute hepatocellular and cholestatic injury during therapy with hydrochlorothiazide - clinicohistopathologic findings: a case report.氢氯噻嗪治疗期间的急性肝细胞性和胆汁淤积性损伤——临床组织病理学发现：一例报告

J Med Case Rep. 2010 Oct 21;4:332. doi: 10.1186/1752-1947-4-332.

Beyond the classic angiotensin-receptor-blocker profile.超越经典血管紧张素受体阻滞剂的特性。

Nat Clin Pract Cardiovasc Med. 2008 Jul;5 Suppl 1:S19-26. doi: 10.1038/ncpcardio0805.

Recognizing drug-induced liver injury: current problems, possible solutions.识别药物性肝损伤：当前问题与可能的解决方案。

Toxicol Pathol. 2005;33(1):155-64. doi: 10.1080/01926230590522356.

Hydrochlorothiazide induced hepato-cholestatic liver injury.

Age Ageing. 2004 Sep;33(5):509-10. doi: 10.1093/ageing/afh148. Epub 2004 Jul 22.

Drug-induced liver injury.药物性肝损伤

Clin Infect Dis. 2004 Mar 1;38 Suppl 2:S44-8. doi: 10.1086/381446.

Valsartan-induced hepatotoxicity in a HBs-Ag-Positive patient.

Am J Gastroenterol. 2003 Feb;98(2):507. doi: 10.1111/j.1572-0241.2003.07248.x.

Cholestatic hepatitis related to use of irbesartan: a case report and a literature review of angiotensin II antagonist-associated hepatotoxicity.与厄贝沙坦使用相关的胆汁淤积性肝炎：一例病例报告及血管紧张素II拮抗剂相关肝毒性的文献综述

Eur J Gastroenterol Hepatol. 2002 Aug;14(8):887-90. doi: 10.1097/00042737-200208000-00014.

Drug-induced liver diseases.药物性肝病

J Hepatol. 2000;32(1 Suppl):77-88. doi: 10.1016/s0168-8278(00)80417-1.

Losartan-induced hepatotoxicity.氯沙坦诱发的肝毒性。

JAMA. 1997 Nov 19;278(19):1572.

Marked hepatotoxicity associated with losartan treatment.与氯沙坦治疗相关的显著肝毒性。

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