Lawen Alfons
Alfons Lawen, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.
World J Biol Chem. 2015 Aug 26;6(3):78-82. doi: 10.4331/wjbc.v6.i3.78.
Iron metabolism is regulated on the cellular and the systemic level. Over the last decade, the liver peptide "hepcidin" has emerged as the body's key irons store regulator. The long postulated "erythroid regulator of iron", however, remained elusive. Last year, evidence was provided, that a previously described myokine "myonectin" may also function as the long sought erythroid regulator of iron. Myonectin was therefore re-named "erythroferrone". This editorial provides a brief discussion on the two functions of erythroferrone and also briefly considers the emerging potential role of transferrin receptor 2 in erythropoiesis.
铁代谢在细胞水平和全身水平受到调节。在过去十年中，肝脏肽“铁调素”已成为人体关键的铁储存调节因子。然而，长期以来假定的“铁的红细胞调节因子”仍然难以捉摸。去年，有证据表明，一种先前描述的肌动蛋白“肌连接蛋白”也可能作为长期寻找的铁的红细胞调节因子发挥作用。因此，肌连接蛋白被重新命名为“铁调素”。这篇社论简要讨论了铁调素的两种功能，并简要考虑了转铁蛋白受体2在红细胞生成中新兴的潜在作用。
