阐明朊病毒构象的技术。
Techniques to elucidate the conformation of prions.
作者信息
Daus Martin L
机构信息
Martin L Daus, ZBS6 - Proteomics and Spectroscopy, Robert Koch-Institute, 13353 Berlin, Germany.
出版信息
World J Biol Chem. 2015 Aug 26;6(3):218-22. doi: 10.4331/wjbc.v6.i3.218.
Abstract
Proteinaceous infectious particles (prions) are unique pathogens as they are devoid of any coding nucleic acid. Whilst it is assumed that prion disease is transmitted by a misfolded isoform of the cellular prion protein, the structural insight of prions is still vague and research for high resolution structural information of prions is still ongoing. In this review, techniques that may contribute to the clarification of the conformation of prions are presented and discussed.
摘要
蛋白质传染性颗粒（朊病毒）是独特的病原体，因为它们不含任何编码核酸。虽然人们认为朊病毒疾病是由细胞朊病毒蛋白的错误折叠异构体传播的，但朊病毒的结构洞察仍然模糊，对朊病毒高分辨率结构信息的研究仍在进行中。在这篇综述中，介绍并讨论了可能有助于阐明朊病毒构象的技术。
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