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电休克治疗对持续性甲基苯丙胺精神病的疗效：一项初步研究。

Effectiveness of Electroconvulsive Therapy in Persistent Methamphetamine Psychosis: A Pilot Study.

作者信息

Ziaaddini Hassan, Roohbakhsh Toktam, Nakhaee Nouzar, Ghaffari-Nejad Alireza

机构信息

Professor, Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Resident, Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

出版信息

Addict Health. 2015 Winter-Spring;7(1-2):14-23.

PMID:26322206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4530189/
Abstract

BACKGROUND

Persistent methamphetamine (METH) psychosis is a psychotic state beyond 1-month after abstinence, for which there is no effective treatment. This study aimed to evaluate the effectiveness of electroconvulsive therapy (ECT) in persistent METH psychosis patients hospitalized at Shahid Beheshti Hospital, Kerman, Iran, from 6 September 2012 until 6 September 2013, who were not remitted after treatment with olanzapine.

METHODS

This research was a pilot study on hospitalized patients. After 4 weeks of treatment with olanzapine, 10 out of 71 studied patients did not show complete remission of psychotic symptoms despite their response to the treatment. The mentioned 10 patients were divided into 2 groups by random digit numbers. 5 patients had continued olanzapine and other 5 received 6 sessions of bilateral ECT every other day in addition to olanzapine.

FINDINGS

Remission rate of patients in the initial 4 weeks was 78.7%. Reduction in total brief psychiatric rating scale (BPRS) scale at the end of 1-week compared with the next week demonstrated improvement in the symptoms until the end of the study. There was no significant difference in BPRS scores between weeks 4 and 6 in the two groups.

CONCLUSION

This research demonstrated that few sessions of ECT in persistent METH psychosis will not lead to remission in all patients.

摘要

背景

持续性甲基苯丙胺（METH）所致精神障碍是戒断1个月后仍存在的一种精神病状态，对此尚无有效治疗方法。本研究旨在评估2012年9月6日至2013年9月6日期间在伊朗克尔曼市沙希德·贝赫什提医院住院的持续性METH所致精神障碍患者接受电休克治疗（ECT）的有效性，这些患者在接受奥氮平治疗后未缓解。

方法

本研究是一项针对住院患者的试点研究。在用奥氮平治疗4周后，71名研究患者中有10名尽管对治疗有反应，但精神病症状未完全缓解。上述10名患者通过随机数字法分为2组。5名患者继续使用奥氮平，另外5名除奥氮平外，每隔一天接受6次双侧ECT治疗。

结果

最初4周患者的缓解率为78.7%。与下一周相比，在第1周结束时总简明精神病评定量表（BPRS）评分降低，表明直到研究结束症状都在改善。两组在第4周和第6周时BPRS评分无显著差异。

结论

本研究表明，持续性METH所致精神障碍患者接受少量ECT治疗不会使所有患者缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755d/4530189/2af7b5d7e558/AHJ-07-014f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755d/4530189/4b7335b8099f/AHJ-07-014f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755d/4530189/2af7b5d7e558/AHJ-07-014f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755d/4530189/4b7335b8099f/AHJ-07-014f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755d/4530189/2af7b5d7e558/AHJ-07-014f2.jpg

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本文引用的文献

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Emergence of a methamphetamine crisis in Iran.伊朗甲基苯丙胺危机的出现。
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