肥胖小鼠的血清炎症标志物：胃饥饿素的作用。
Serum inflammatory markers in obese mice: Effect of ghrelin.
作者信息
Khazaei Majid, Tahergorabi Zoya
机构信息
Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Birjand University of Medical Sciences, Birjand, Iran.
出版信息
Adv Biomed Res. 2015 Jul 27;4:145. doi: 10.4103/2277-9175.161556. eCollection 2015.
Abstract
BACKGROUND
Ghrelin is involved in modulation of food intake and energy homeostasis; however, it may play a role in cardiovascular system and atherosclerosis process. This study aimed to investigate the effect of ghrelin on serum inflammatory markers in control and obese mice.
MATERIALS AND METHODS
Ghrelin (100 mg/kg/day, twice daily) was administered interaperitoneally to control and diet-induced obese mice. After 10 days, blood samples were taken.
RESULTS
Results showed that administration of ghrelin did not change serum hsCRP level; however, it reduced serum IL-6 concentration in obese mice (P < 0.05).
CONCLUSION
It seems that the exact role and mechanism of ghrelin in prevention or treatment of atherosclerosis needs more studies.
摘要
背景
胃饥饿素参与食物摄入和能量平衡的调节；然而，它可能在心血管系统和动脉粥样硬化过程中发挥作用。本研究旨在探讨胃饥饿素对正常小鼠和肥胖小鼠血清炎症标志物的影响。
材料与方法
对正常小鼠和饮食诱导的肥胖小鼠腹腔注射胃饥饿素（100毫克/千克/天，每日两次）。10天后采集血样。
结果
结果显示，注射胃饥饿素并未改变血清高敏C反应蛋白水平；然而，它降低了肥胖小鼠血清白细胞介素-6浓度（P<0.05）。
结论
胃饥饿素在预防或治疗动脉粥样硬化中的确切作用和机制似乎需要更多研究。
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