Jaafari-Ashkavandi Zohreh, Pardis Soheil, Asadzadeh Maryam, Andisheh-Tadbir Azadeh, Dehghani-Nazhvani Ali
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, SHIRAZ, IRAN.
Turk Patoloji Derg. 2014;30(2):94-9. doi: 10.5146/tjpath.2014.01241.
The aim of this study is to evaluate the caveolin-1 expression in a group of odontogenic cysts and tumors.
In this cross-sectional study, the expression of caveolin-1 was evaluated immunohistochemically in 75 samples including 18 cases of dentigerous cyst, 18 odontogenic keratocysts, 3 orthokeratinized odontogenic cysts, 2 calcifying odontogenic cysts and 34 ameloblastomas (solid and unicystic).
Positive immunohistochemical reaction was found in 100% of odontogenic cysts and this was significantly more than both unicystic (65%) and solid (55%) ameloblastomas.
The present study showed the expression of caveolin-1 in all odontogenic cysts and more than ameloblastomas. The results suggested that absence of caveolin-1 might enhance aggressiveness of odontogenic lesions and could be a useful marker for distinguishing ameloblastomas from other odontogenic lesions.
本研究旨在评估一组牙源性囊肿和肿瘤中小窝蛋白-1的表达情况。
在这项横断面研究中，采用免疫组织化学方法评估了75个样本中小窝蛋白-1的表达，这些样本包括18例含牙囊肿、18例牙源性角化囊肿、3例正角化型牙源性囊肿、2例钙化性牙源性囊肿和34例成釉细胞瘤（实性和单囊性）。
在100%的牙源性囊肿中发现了阳性免疫组织化学反应，这显著高于单囊性成釉细胞瘤（65%）和实性成釉细胞瘤（55%）。
本研究显示小窝蛋白-1在所有牙源性囊肿中均有表达，且表达水平高于成釉细胞瘤。结果表明，小窝蛋白-1的缺失可能会增强牙源性病变的侵袭性，并且可能是区分成釉细胞瘤与其他牙源性病变的有用标志物。
