Sacrey Lori-Ann R, Bennett Jeffrey A, Zwaigenbaum Lonnie
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Autism Research Centre, Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
J Child Neurol. 2015 Dec;30(14):1921-9. doi: 10.1177/0883073815601500. Epub 2015 Aug 31.
The objective is to overview recent findings on early detection/diagnosis of autism spectrum disorders, as well as clinical trials of early interventions for toddlers at risk for/diagnosed with autism spectrum disorder.
Prospective studies of infants at high risk of autism spectrum disorder have yielded significant advances in understanding early development in autism spectrum disorder. Findings from prospective studies indicate that abnormalities in social communication and repetitive behaviors emerge during the second year, whereas additional "prodromal features" (motor and sensory abnormalities) emerge in the first year. Subsequently, exciting progress has been made in establishing the efficacy of autism spectrum disorder-specific interventions for toddlers as young as 15 months. Finally, efforts occur to characterize autism spectrum disorder-specific characteristics in genetic syndromes with concurrent autism spectrum disorder symptomatology.
Substantial progress in characterizing early developmental trajectories as well as the identification of specific behavioral markers has aided early detection. Work remains to ensure that research findings are translated into clinical practice for uptake in the health care system.
概述自闭症谱系障碍早期检测/诊断的最新研究结果,以及针对有自闭症谱系障碍风险/已被诊断为自闭症谱系障碍的幼儿的早期干预临床试验。
对自闭症谱系障碍高风险婴儿的前瞻性研究在理解自闭症谱系障碍的早期发展方面取得了重大进展。前瞻性研究结果表明,社交沟通和重复行为异常在第二年出现,而其他“前驱特征”(运动和感觉异常)在第一年出现。随后,在确定针对15个月大幼儿的自闭症谱系障碍特异性干预措施的有效性方面取得了令人兴奋的进展。最后,人们努力在伴有自闭症谱系障碍症状的遗传综合征中表征自闭症谱系障碍的特异性特征。
在表征早期发育轨迹以及识别特定行为标志物方面取得的实质性进展有助于早期检测。仍需努力确保将研究结果转化为临床实践,以便在医疗保健系统中应用。