Rivas-Santiago Bruno, Castañeda-Delgado Julio E, de Haro-Acosta Jeny, Torres-Juarez Flor, Frausto-Lujan Isabel, Marin-Luevano Paulina, González-Amaro Roberto, Enciso-Moreno Jose A
Medical Research Unit of Zacatecas, Mexican Institute of Social Security, UIMZ-IMSS, Interior de la alameda # 45 col centro, Zacatecas, Mexico.
Catedras-CONACyT, National Council of Science and Technology (CONACyT), Mexico City, Mexico.
Immunol Res. 2016 Apr;64(2):445-54. doi: 10.1007/s12026-015-8689-2.
Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has not been described. In the present study, we addressed the question whether antimicrobial activity in polymorphonuclear cells from elderly individuals was altered in comparison with young adults. We compared phagocytosis index, bacterial killing efficiency, myeloperoxidase activity and cathelicidin expression. Results showed that there were no statistical differences among groups. However, human neutrophil peptide-1 (HNP-1) was decreased in the elderly individuals group. Results suggest that the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases.
抗菌肽固有免疫在传染病易感性中起着核心作用，这在不同情况下已有广泛描述。然而，这些分子在作为老年个体固有免疫一部分的多形核吞噬细胞介导的免疫中所起的作用尚未见报道。在本研究中，我们探讨了老年个体多形核细胞中的抗菌活性与年轻成年人相比是否发生改变。我们比较了吞噬指数、细菌杀伤效率、髓过氧化物酶活性和cathelicidin表达。结果显示各组之间无统计学差异。然而，老年个体组中人类嗜中性粒细胞肽-1（HNP-1）减少。结果表明，老年个体多形核吞噬细胞中HNP-1产生的减少可能在对传染病易感性增加中起重要作用。
