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巴西神经肌肉阻滞剂的使用情况。

Use of neuromuscular blockers in Brazil.

作者信息

Locks Giovani de Figueiredo, Cavalcanti Ismar Lima, Duarte Nadia Maria Conceição, da Cunha Rafael Martins, de Almeida Maria Cristina Simões

机构信息

Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

出版信息

Braz J Anesthesiol. 2015 Sep-Oct;65(5):319-25. doi: 10.1016/j.bjane.2015.03.001. Epub 2015 Aug 15.

DOI:10.1016/j.bjane.2015.03.001
PMID:26323727
Abstract

The objective of this study was to evaluate how Brazilian anesthesiologists are using neuromuscular blockers, focusing on how they establish the diagnosis of postoperative residual curarization and the incidence of complications associated with the use of neuromuscular blockers. A questionnaire was sent to anesthesiologists inviting them to participate in the study. The online data collection remained open from March 2012 to June 2013. During the study period, 1296 responses were collected. Rocuronium, atracurium, and cisatracurium were the main neuromuscular blockers used in cases of elective surgery. Succinylcholine and rocuronium were the main neuromuscular blockers used in cases of emergency surgery. Less than 15% of anesthesiologists reported the frequent use of neuromuscular function monitors. Only 18% of those involved in the study reported that all workplaces have such a monitor. Most respondents reported using only the clinical criteria to assess whether the patient is recovered from the muscle relaxant. Most respondents also reported always using some form of neuromuscular blockade reversal. The major complications attributed to neuromuscular blockers were residual curarization and prolonged blockade. Eighteen anesthesiologists reported death attributed to neuromuscular blockers. Residual or prolonged blockade is possibly recorded as a result of the high rate of using clinical criteria to diagnose whether the patient has recovered or not from motor block and, as a corollary, the poor use of neuromuscular transmission monitors in daily practice.

摘要

本研究的目的是评估巴西麻醉医生如何使用神经肌肉阻滞剂,重点关注他们如何确立术后残余肌松的诊断以及与神经肌肉阻滞剂使用相关的并发症发生率。向麻醉医生发送了一份问卷,邀请他们参与研究。在线数据收集从2012年3月持续至2013年6月。在研究期间,共收集到1296份回复。罗库溴铵、阿曲库铵和顺式阿曲库铵是择期手术中使用的主要神经肌肉阻滞剂。琥珀酰胆碱和罗库溴铵是急诊手术中使用的主要神经肌肉阻滞剂。不到15%的麻醉医生报告经常使用神经肌肉功能监测仪。参与研究的人中只有18%报告所有工作场所都有这种监测仪。大多数受访者报告仅使用临床标准来评估患者是否已从肌肉松弛状态恢复。大多数受访者还报告总是使用某种形式的神经肌肉阻滞逆转。归因于神经肌肉阻滞剂的主要并发症是残余肌松和阻滞时间延长。18名麻醉医生报告有因神经肌肉阻滞剂导致的死亡。由于使用临床标准诊断患者是否已从运动阻滞中恢复的比例很高,以及相应地在日常实践中神经肌肉传递监测仪使用不佳,残余或延长的阻滞可能被记录下来。

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1
Use of neuromuscular blockers in Brazil.巴西神经肌肉阻滞剂的使用情况。
Braz J Anesthesiol. 2015 Sep-Oct;65(5):319-25. doi: 10.1016/j.bjane.2015.03.001. Epub 2015 Aug 15.
2
[Use of neuromuscular blockers in Brazil].[巴西神经肌肉阻滞剂的使用]
Rev Bras Anestesiol. 2015 Sep-Oct;65(5):319-25. doi: 10.1016/j.bjan.2015.03.001. Epub 2015 Jul 6.
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[Neuromuscular blockers in Brazil.].[巴西的神经肌肉阻滞剂。]
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Reversal with sugammadex in the absence of monitoring did not preclude residual neuromuscular block.在没有监测的情况下使用 sugammadex 逆转未能排除残余神经肌肉阻滞。
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The RECITE Study: A Canadian Prospective, Multicenter Study of the Incidence and Severity of Residual Neuromuscular Blockade.RECIte 研究:加拿大一项关于残余神经肌肉阻滞发生率和严重程度的前瞻性、多中心研究。
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A survey of the current use of neuromuscular blocking drugs among the Middle Eastern anesthesiologists.中东麻醉医师当前使用神经肌肉阻滞药物的情况调查。
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Reversal of Pipecuronium-Induced Moderate Neuromuscular Block with Sugammadex in the Presence of a Sevoflurane Anesthetic: A Randomized Trial.罗库溴铵诱导的中度神经肌肉阻滞用 sugammadex 逆转:七氟醚麻醉下的随机试验。
Anesth Analg. 2015 Aug;121(2):373-80. doi: 10.1213/ANE.0000000000000766.

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Neuromuscular Blocking Agents and Monitoring in China: A Cross-Sectional Survey of Current Management.中国的神经肌肉阻滞剂与监测:当前管理的横断面调查
Front Med (Lausanne). 2022 Apr 27;9:770105. doi: 10.3389/fmed.2022.770105. eCollection 2022.
2
A multicenter survey on the use of neuromuscular blockade in Greece. Does the real-world clinical practice indicate the necessity of guidelines?希腊关于神经肌肉阻滞使用情况的多中心调查。实际临床实践是否表明需要指南?
J Anaesthesiol Clin Pharmacol. 2019 Apr-Jun;35(2):202-214. doi: 10.4103/joacp.JOACP_195_18.
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Use Profile of Magnesium Sulfate in Anesthesia in Brazil.
巴西硫酸镁在麻醉中的应用概况
Front Pharmacol. 2019 Apr 26;10:429. doi: 10.3389/fphar.2019.00429. eCollection 2019.
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[Sugammadex by ideal body weight versus 20% and 40% corrected weight in bariatric surgery - double-blind randomized clinical trial].[肥胖症手术中按理想体重与20%及40%校正体重使用舒更葡糖钠——双盲随机临床试验]
Braz J Anesthesiol. 2018 May-Jun;68(3):219-224. doi: 10.1016/j.bjan.2017.10.010. Epub 2018 Jan 5.