Singh J, Garg K N, Garg D, Chugh K, Lal H
Indian J Exp Biol. 1989 Jul;27(7):621-4.
Cardiac necrosis was produced in rats by administering isoproterenol sulphate (85 mg/kg, sc for 4 days). The myocardial damage was proved by observing the elevated levels of serum aspartate amino-transferase, lactate dehydrogenase and creatine phosphokinase and the changes were confirmed by histopathology of the tissue. Both aspartate and glutamate (100 mg/kg, ip) significantly reduced the elevated levels of these enzymes. The average degree of cardiac necrosis produced in these rats when observed macroscopically and histologically was also found to be significantly reduced on pretreatment with aspartate and glutamate.
通过给予硫酸异丙肾上腺素（85毫克/千克，皮下注射，共4天）在大鼠中造成心脏坏死。通过观察血清天冬氨酸转氨酶、乳酸脱氢酶和肌酸磷酸激酶水平升高来证实心肌损伤，并且这些变化通过组织的组织病理学得到确认。天冬氨酸和谷氨酸（100毫克/千克，腹腔注射）均显著降低了这些酶的升高水平。当宏观和组织学观察时，还发现这些大鼠在经天冬氨酸和谷氨酸预处理后产生的心脏坏死平均程度也显著降低。
