Hou Xin, Gao Yuhua, Duan Yongjian, Wang Zhiwei, Shi Lei, Ma Jincheng, Xie Xuanhu
Department of Oncology, The First Affiliated Hospital of Henan University, Henan, Kaifeng 475000, PR China.
J Cancer Res Ther. 2015 Aug;11 Suppl 1:C97-100. doi: 10.4103/0973-1482.163854.
The association between the myeloperoxidase (MPO) 463 G>A polymorphism and lung cancer risk remains controversial. We perform this meta-analysis to further evaluate the MPO 463G>A polymorphism and lung cancer susceptibility.
We performed the systemic literature search in PubMed, EMBASE, WANFANG, and CNKI databases for molecular epidemiologic studies on the association of MPO 463G>A polymorphism and lung cancer susceptibility. The pooled odds ratio (OR) of MPO 463G>A polymorphism and lung cancer risk were calculated by random or fixed effect model.
Seven case-control studies including 1538 lung cancer patients in the case group and 1673 healthy controls in the control group were included in this study. MPO 463G>A polymorphism was not associated with lung cancer susceptibility under the condition of recessive genetic model (AA vs. GG+GA) (OR = 0.69, P > 0.05) and homozygous genetic model (AA vs. GG) (OR = 0.65, P > 0.05). However, we found significantly decreased risk of lung cancer under dominant genetic model (GA+AA vs. GG) (OR = 0.84, P < 0.05). And no publication bias was found in this meta-analysis for the three genetic models (P > 0.05).
This meta-analysis indicated that people with AA genetic type may have decreased lung cancer risk under dominant genetic model.
髓过氧化物酶（MPO）463G>A多态性与肺癌风险之间的关联仍存在争议。我们进行这项荟萃分析以进一步评估MPO 463G>A多态性与肺癌易感性。
我们在PubMed、EMBASE、万方和知网数据库中进行了系统的文献检索，以查找关于MPO 463G>A多态性与肺癌易感性关联的分子流行病学研究。通过随机或固定效应模型计算MPO 463G>A多态性与肺癌风险的合并比值比（OR）。
本研究纳入了7项病例对照研究，病例组包括1538例肺癌患者，对照组包括1673例健康对照。在隐性遗传模型（AA与GG+GA）（OR = 0.69，P>0.05）和纯合子遗传模型（AA与GG）（OR = 0.65，P>0.05）条件下，MPO 463G>A多态性与肺癌易感性无关。然而，我们发现在显性遗传模型（GA+AA与GG）下肺癌风险显著降低（OR = 0.84，P<0.05）。并且在该荟萃分析中，三种遗传模型均未发现发表偏倚（P>0.05）。
这项荟萃分析表明，在显性遗传模型下，AA基因型的人可能肺癌风险降低。
