Varshney A C, Singh H, Gupta R S, Singh S P
Indian J Exp Biol. 1989 Sep;27(9):816-9.
Osteomyelitis was induced in 45 male dogs by inoculating hemolytic strain of Staphylococcus aureus alone into the tibial marrow cavity. Clinical, radiological and bacteriological studies were conducted to evaluate the progress of disease up to 15 weeks. Clinical signs consisted of localized soft tissue swelling, pain, pyrexia and lameness which later developed an open wound with purulent exudation. Predominant radiographic features were extensive periosteal reaction, cortical lysis, new bone formation, frequent development of sequestrum and formation of localized abscess pockets in advanced cases. Staphylococci were recovered from the tibial marrow cavity for as long as 15 weeks after onset of the infection.
通过将溶血性金黄色葡萄球菌单独接种到45只雄性犬的胫骨骨髓腔中诱导骨髓炎。进行了临床、放射学和细菌学研究，以评估长达15周的疾病进展情况。临床症状包括局部软组织肿胀、疼痛、发热和跛行，随后发展为有脓性渗出物的开放性伤口。主要的放射学特征是广泛的骨膜反应、皮质溶解、新骨形成、死骨的频繁形成以及晚期病例中局部脓肿腔的形成。感染开始后长达15周，均可从胫骨骨髓腔中分离出葡萄球菌。
