Agarwal R K, Pandey U S, Dixit K S, Shukla N, Singh S K
Indian J Med Sci. 1989 Dec;43(12):323-8.
A study was carried out to determine the involvement of dopaminergic system in opioid-induced cardiovascular responses in the dogs. The study population consisted of 32 mongrel dogs of either sexes. The results show that morphine given in small dose (2 mg/kg I.V.) causes significant fall in blood pressure. The results also show that there is involvement of dopaminergic system in opioid-induced vasomotor responses in dogs. Partial blockade of the parenterally induced hypotensive response of morphine by haloperidol given centrally induced hypotensive responses of morphine by haloperidol given centrally in doses, which are too low to be effective by the peripheral route, strongly favours the involvement of central dopaminergic system in the morphine-induced hypotensive responses. The results also show that the hypotensive response of morphine was almost completely blocked after naloxone pretreatment by central route.
进行了一项研究以确定多巴胺能系统在阿片类药物引起的犬类心血管反应中的作用。研究对象包括32只雌雄不限的杂种犬。结果表明，小剂量静脉注射吗啡（2毫克/千克）会导致血压显著下降。结果还表明，多巴胺能系统参与了阿片类药物引起的犬类血管舒缩反应。通过中枢给予氟哌啶醇，以低至外周途径无效的剂量部分阻断了吗啡经胃肠外给药引起的降压反应，这有力地支持了中枢多巴胺能系统参与吗啡诱导的降压反应。结果还表明，经中枢途径预先给予纳洛酮后，吗啡的降压反应几乎完全被阻断。
