ACTN3基因R577X基因型与一大群日本运动员的运动表现

ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes.

作者信息

Kikuchi Naoki, Miyamoto-Mikami Eri, Murakami Haruka, Nakamura Tomohiro, Min Seok-Ki, Mizuno Masuhiko, Naito Hisashi, Miyachi Motohiko, Nakazato Koichi, Fuku Noriyuki

机构信息

a Sports Training Center , Nippon Sport Science University , Tokyo , Japan.

b Faculty of Sport and Health Science , Ritsumeikan University , Shiga , Japan.

出版信息

Eur J Sport Sci. 2016 Sep;16(6):694-701. doi: 10.1080/17461391.2015.1071879. Epub 2015 Sep 1.

DOI:10.1080/17461391.2015.1071879

PMID:26324221

Abstract

AIM

Recent meta-analyses of the literature confirmed the association between the RR+RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athletic status in Europeans but not in Asians and Africans, while the association between the R577X genotype and elite endurance athlete status is less convincing. The aim of the present study was to investigate the association between the ACTN3 R577X genotype and elite athlete status in a large Asian (Japanese) cohort of track and field athletes.

METHODS

One-thousand fifty-seven Japanese track and field athletes (627 sprint/power athletes and 430 endurance athletes) and 810 Japanese controls were genotyped for the ACTN3 R577X polymorphism (rs1815739) by using the TaqMan® SNP Genotyping Assay.

RESULTS

Elite sprint/power athletes had a higher frequency of the RR+RX genotype than the controls (OR: 1.59, 95% CI: 1.16-2.18; P = .003). A significant linear correlation was found between the RR + RX genotype and athlete status (i.e. regional < national < international) in sprint/power athletes (regional: 71%, national: 81%, international: 84%; P = .001 for trend) and long-distance runners (regional: 65%, national: 72%, international: 82%; P = .030 for trend).

CONCLUSIONS

The data obtained for this large Asian (Japanese) cohort of track and field athletes served to confirm the association between the RR + RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athlete status and also the association between the ACTN3 RR + RX genotype and long-distance running athletic status.

摘要

目的

近期对文献的荟萃分析证实，ACTN3基因R577X多态性的RR + RX基因型与欧洲人的精英短跑/力量型运动状态相关，但在亚洲人和非洲人中并非如此，而R577X基因型与精英耐力型运动员状态之间的关联则不太令人信服。本研究的目的是在一个大型亚洲（日本）田径运动员队列中调查ACTN3基因R577X多态性与精英运动员状态之间的关联。

方法

采用TaqMan® SNP基因分型检测法，对1057名日本田径运动员（627名短跑/力量型运动员和430名耐力型运动员）和810名日本对照者进行ACTN3基因R577X多态性（rs1815739）基因分型。

结果

精英短跑/力量型运动员的RR + RX基因型频率高于对照组（比值比：1.59，95%置信区间：1.16 - 2.18；P = 0.003）。在短跑/力量型运动员（地区级：71%，国家级：81%，国际级：84%；趋势P = 0.001）和长跑运动员（地区级：65%，国家级：72%，国际级：82%；趋势P = 0.030）中，RR + RX基因型与运动员状态（即地区级 < 国家级 < 国际级）之间存在显著的线性相关性。