Patel Rashmin B, Thakore Shivam D, Patel Mrunali R
A.R. College of Pharmacy & G. H. Patel Institute of Pharmacy, Vallabh Vidyanagar - 388120, Anand, Gujarat, India.
Curr Drug Deliv. 2016;13(6):857-81. doi: 10.2174/1567201812666150901111930.
Colloidal systems are most prominent delivery systems mainly used as vehicles for the transportation, targeting the various types of biomolecules, proteins, peptides, synthetic medicinal agents.
To provide concise information on patents that are directly or indirectly related to the nanoemulsions.
The ample of research work going on with such system, in which small insoluble particle/droplets are dispersed within the immiscible secondary liquid referred to as continuous phase, is enormous. A highly praised colloidal system is nanoemulsion which possesses 'nano' sized droplets of one phase dispersed within second continuous phase.
The characteristic features of nanoemulsion are their optical clarity, clear or bluish tint appearance and small globule size (20-200 nm) which makes them insensitive to gravitational instability, dilution and temperature. Above of all, achieving said properties using lower surfactant concentration and by supplying external energy differentiate them from microemulsion, which uses higher amount of surfactant thereby making them toxic for human body. Due to such variable advantages, researchers are engaged in going for the protecting their ideas in nanoemulsions by filling various patents.
Patents in this review, covers various areas (types of drug delivery and applications) where nanoemulsion are used. Literature revealed that filing of patents on nanoemulsion increased tremendously during last 5 years and will increase in upcoming time as 21st century will be called as the century of nanomedicine.
胶体系统是最突出的给药系统，主要用作运输载体，用于输送各种生物分子、蛋白质、肽和合成药物制剂。
提供与纳米乳剂直接或间接相关的专利的简要信息。
关于此类系统的研究工作很多，在该系统中，小的不溶性颗粒/液滴分散在称为连续相的不混溶的第二液相中。一种备受赞誉的胶体系统是纳米乳剂，它具有“纳米”尺寸的一相液滴分散在第二连续相中。
纳米乳剂的特征是其光学澄清度、清澈或带蓝色调的外观以及小球体尺寸（20 - 200纳米），这使得它们对重力不稳定性、稀释和温度不敏感。最重要的是，使用较低的表面活性剂浓度并通过提供外部能量来实现上述特性，这使它们与微乳剂有所不同，微乳剂使用较高量的表面活性剂，从而对人体有毒。由于这些多样的优点，研究人员通过申请各种专利来保护他们在纳米乳剂方面的想法。
本综述中的专利涵盖了使用纳米乳剂的各个领域（药物递送类型和应用）。文献表明，在过去5年中，关于纳米乳剂的专利申请大幅增加，并且在未来还会增加，因为21世纪将被称为纳米医学的世纪。
