Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Amity Institute of Pharmacy, Amity University, Lucknow Campus, Lucknow, 226028, India.
J Control Release. 2017 Apr 28;252:28-49. doi: 10.1016/j.jconrel.2017.03.008. Epub 2017 Mar 6.
Nanoemulsions are biphasic dispersion of two immiscible liquids: either water in oil (W/O) or oil in water (O/W) droplets stabilized by an amphiphilic surfactant. These come across as ultrafine dispersions whose differential drug loading; viscoelastic as well as visual properties can cater to a wide range of functionalities including drug delivery. However there is still relatively narrow insight regarding development, manufacturing, fabrication and manipulation of nanoemulsions which primarily stems from the fact that conventional aspects of emulsion formation and stabilization only partially apply to nanoemulsions. This general deficiency sets up the premise for current review. We attempt to explore varying intricacies, excipients, manufacturing techniques and their underlying principles, production conditions, structural dynamics, prevalent destabilization mechanisms, and drug delivery applications of nanoemulsions to spike interest of those contemplating a foray in this field.
水包油（W/O）或油包水（O/W）液滴，由两亲性表面活性剂稳定。这些都是超细分散体，其差异药物负载；粘弹性和视觉特性可以满足包括药物输送在内的广泛功能。然而，对于纳米乳剂的开发、制造、制造和操作，仍然相对缺乏了解，这主要是因为乳液形成和稳定的常规方面仅部分适用于纳米乳剂。这种普遍的不足为本次综述奠定了基础。我们试图探讨纳米乳剂的各种复杂性、赋形剂、制造技术及其基本原理、生产条件、结构动力学、常见的失稳机制以及药物输送应用，以激发那些有兴趣涉足该领域的人的兴趣。
