Zhou Zhenyu, He Chuanchao, Wang Jie
Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China.
Oncol Rep. 2015 Nov;34(5):2215-24. doi: 10.3892/or.2015.4227. Epub 2015 Aug 26.
F-box and WD repeat domain-containing 7 (Fbxw7), the substrate-recognition component of SCFFbxw7 complex, is thought to be a tumor suppressor involved in cell growth, proliferation, differentiation and survival. Although an increasing number of ubiquitin substrates of Fbxw7 have been identified, the best characterized substrates are cyclin E and c-Myc. Fbxw7/cyclin E and Fbxw7/c-Myc pathways are tightly regulated by multiple regulators. Fbxw7 has been identified as a tumor suppressor in hepatocellular carcinoma. This review focused on the regulation of Fbxw7/cyclin E and Fbxw7/c-Myc pathways and discussed findings to gain a better understanding of the role of Fbxw7 in hepatocellular carcinoma.
含F-box和WD重复结构域7（Fbxw7）是SCFFbxw7复合物的底物识别成分，被认为是一种参与细胞生长、增殖、分化和存活的肿瘤抑制因子。尽管已鉴定出越来越多Fbxw7的泛素化底物，但最具特征的底物是细胞周期蛋白E和c-Myc。Fbxw7/细胞周期蛋白E和Fbxw7/c-Myc途径受到多种调节因子的严格调控。Fbxw7已被确定为肝细胞癌中的一种肿瘤抑制因子。本综述重点关注Fbxw7/细胞周期蛋白E和Fbxw7/c-Myc途径的调控，并讨论相关研究结果，以更好地理解Fbxw7在肝细胞癌中的作用。
