Zhai Fengguang, Wang Jie, Yang Weili, Ye Meng, Jin Xiaofeng
The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.
Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Cancers (Basel). 2022 Oct 30;14(21):5354. doi: 10.3390/cancers14215354.
Endometrial (EC) and cervical (CC) cancers are the most prevalent malignancies of the female reproductive system. There is a global trend towards increasing incidence and mortality, with a decreasing age trend. E3 ligases label substrates with ubiquitin to regulate their activity and stability and are involved in various cellular functions. Studies have confirmed abnormal expression or mutations of E3 ligases in EC and CC, indicating their vital roles in the occurrence and progression of EC and CC. This paper provides an overview of the E3 ligases implicated in EC and CC and discusses their underlying mechanism. In addition, this review provides research advances in the target of ubiquitination processes in EC and CC.
子宫内膜癌（EC）和宫颈癌（CC）是女性生殖系统中最常见的恶性肿瘤。全球范围内，其发病率和死亡率呈上升趋势，且发病年龄呈下降趋势。E3连接酶通过给底物标记泛素来调节其活性和稳定性，并参与多种细胞功能。研究证实，EC和CC中E3连接酶存在异常表达或突变，表明它们在EC和CC的发生发展中起着至关重要的作用。本文概述了与EC和CC相关的E3连接酶，并讨论了其潜在机制。此外，本综述还介绍了EC和CC中泛素化过程靶点的研究进展。
