Steinestel K, Wardelmann E
Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Domagkstr. 17, 48149, Münster, Deutschland.
Pathologe. 2015 Nov;36 Suppl 2:167-70. doi: 10.1007/s00292-015-0072-5.
Invasion and metastatic dissemination of tumor cells defines prognosis not only in patients with epithelial, but also mesenchymal neoplasms. Early and clinically inapparent micrometastases occur in many patients, and the risk for metastasis correlates with the tumor subtype and histologic tumor grade. In recent years and analogous to the situation in epithelial tumors, mechanisms of tumor cell dissemination in soft tissue tumors have been increasingly understood, and it has been shown that reorganization of the actin cytoskeleton plays a key role in these processes. This review summarizes current knowledge on the mechanisms of progression and metastasis of soft tissue tumors and points out possible targets for novel anti-invasive and anti-metastatic therapies.
肿瘤细胞的侵袭和转移扩散不仅决定上皮性肿瘤患者的预后，也决定间叶性肿瘤患者的预后。许多患者会出现早期且临床上难以察觉的微转移，转移风险与肿瘤亚型和组织学肿瘤分级相关。近年来，类似于上皮性肿瘤的情况，软组织肿瘤中肿瘤细胞扩散的机制已越来越为人所知，并且已表明肌动蛋白细胞骨架的重组在这些过程中起关键作用。本综述总结了关于软组织肿瘤进展和转移机制的当前知识，并指出了新型抗侵袭和抗转移治疗的可能靶点。
