Kremer B, Henne-Bruns D, Kraemer-Hansen H, Harfmann P, Kuhlencordt R, Schröder S
Helv Chir Acta. 1989 Dec;56(4):521-5.
Since 1984 32 liver transplantations were performed at the University of Hamburg in 29 patients. 2-year survival rate of electively grafted patients is 71.4%. Immunosuppression is performed with ciclosporin A, steroids and azathioprine. The diagnosis of rejection episodes or viral infections is established by determination of activated lymphocytes, lymphoblasts or LGL-cells in the peripheral blood or in the graft (aspiration cytology). Additional liver biopsy gives information regarding the extent and kind of a white blood cell infiltrate and furthermore allows a differentiation of T-lymphocytes by immunohistological staining. Rejection episodes are primarily treated with ATG (Fresenius), non responding cases either with ATG (Stanford) or OKT 3. Successful treatment with ATG results in an elimination of T3, T4 and T8-lymphocytes. A sufficient result of OKT 3 treatment is stated after elimination of T3 cells.
自1984年以来，汉堡大学为29例患者实施了32例肝脏移植手术。择期移植患者的2年生存率为71.4%。免疫抑制采用环孢素A、类固醇和硫唑嘌呤。通过测定外周血或移植物（穿刺细胞学）中的活化淋巴细胞、淋巴母细胞或大颗粒淋巴细胞来诊断排斥反应或病毒感染。额外的肝脏活检可提供有关白细胞浸润程度和类型的信息，还可通过免疫组织化学染色区分T淋巴细胞。排斥反应主要用抗胸腺细胞球蛋白（费森尤斯）治疗，无反应的病例则用抗胸腺细胞球蛋白（斯坦福）或OKT 3治疗。抗胸腺细胞球蛋白成功治疗可消除T3、T4和T8淋巴细胞。在消除T3细胞后表明OKT 3治疗效果良好。
