Dalhoff K, Dennin R H, Schulz E, Sack K, Hoyer J
Klinik für Innere Medizin, Medizinische Universität zu Lübeck.
Dtsch Med Wochenschr. 1988 Jun 24;113(25):1017-21. doi: 10.1055/s-2008-1067760.
In 50 patients who had a renal transplantation, treated with ciclosporin, regular monitoring of lymphocyte subpopulations was undertaken prospectively to assess its value with respect to cellular rejection, herpes virus infection, and ciclosporin overdosage. Herpes virus infection was characterized by inversion of the T4/T8 ratio below 1.0 (sensitivity 90%, specificity 88%), caused by proliferation of the T8 subpopulation, which--compared with the findings in patients with rejection crises--was significantly raised (P less than 0.001). But such rejection crises could not be predicted from the T4/T8 ratio. Ciclosporin had no effect on the ratio, total lymphocyte count in this group being higher (P less than 0.002) than in patients with rejection.
对50例接受肾移植并用环孢素治疗的患者进行前瞻性淋巴细胞亚群定期监测，以评估其在细胞排斥、疱疹病毒感染及环孢素过量方面的价值。疱疹病毒感染的特征是T4/T8比值倒置低于1.0（敏感性90%，特异性88%），由T8亚群增殖所致，与排斥危象患者的结果相比，T8亚群显著升高（P<0.001）。但无法根据T4/T8比值预测此类排斥危象。环孢素对此比值无影响，该组患者的总淋巴细胞计数高于排斥患者（P<0.002）。
