2-甲氧基乙醇和2-乙氧基乙醇对2-丁氧基乙醇所致血液学变化的影响。

The effects of 2-methoxyethanol and 2-ethoxyethanol on hematological changes induced by 2-butoxyethanol.

作者信息

Starek-Świechowicz Beata, Miranowicz-Dzierżawska Katarzyna, Budziszewska Bogusława, Starek Andrzej

机构信息

Jagiellonian University / Uniwersytet Jagielloński, Kraków, Poland (Medical College, Faculty of Pharmacy, Department of Biochemical Toxicology / Collegium Medicum, Wydział Farmaceutyczny, Zakład Biochemii Toksykologicznej).

Central Institute for Labour Protection - National Research Institute / Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy, Warszawa, Poland (Department of Chemical, Aerosol and Biological Hazards, Laboratory of Toxicology / Zakład Zagrożeń Chemicznych, Aerozolowych i Biologicznych, Laboratorium Toksykologiczne).

出版信息

Med Pr. 2015;66(3):303-15. doi: 10.13075/mp.5893.00126.

DOI:10.13075/mp.5893.00126

PMID:26325043

Abstract

BACKGROUND

Alkoxyethanols (ethylene glycol alkyl ethers) are used as mixtures in a variety of industrial and household products. The aim of this study has been to evaluate the effects of 2-methoxyethanol (ME) and 2-ethoxyethanol (EE) on hematological changes induced by 2-butoxyethanol (BE) in rats.

MATERIAL AND METHODS

Experiments were performed on male Wistar rats treated subcutaneously with BE, ME, and EE alone (in the dose of 0.75 mM/kg/day and 1.25 mM/kg/day) and their mixtures with the molar ratio 1:1, for 4 weeks. Hematological analyses were performed on the day 0, 4, 11, 18, and 29. Hemoglobin (HGB) concentration in the urine was also determined in the rats treated with BE alone and co-exposed to BE and ME and also BE and EE.

RESULTS

The rats co-exposed to BE and ME or BE and EE demonstrated significantly less pronounced hematological changes in comparison with animals treated with BE alone at the beginning of exposure. At the later period the hematological alterations in the same animals were markedly pronounced and progressing with exposure time. The rats co-exposed to BE and ME or BE and EE did not demonstrate hemoglobinuria.

CONCLUSIONS

ME or EE co-administered to rats with BE lead to the amelioration in the majority of the hematological parameters at the beginning of the exposure. The hematological changes at the end of the co-exposure to BE and ME or BE and EE were markedly pronounced. The effects observed in this study appear to be related with metabolic interactions of the examined ether. Med Pr 2015;66(3):303-315.

摘要

背景

烷氧基乙醇（乙二醇烷基醚）在各种工业和家用产品中以混合物形式使用。本研究的目的是评估2 - 甲氧基乙醇（ME）和2 - 乙氧基乙醇（EE）对大鼠中2 - 丁氧基乙醇（BE）诱导的血液学变化的影响。

材料与方法

对雄性Wistar大鼠进行实验，分别皮下注射单独的BE、ME和EE（剂量为0.75 mM/kg/天和1.25 mM/kg/天）以及它们摩尔比为1:1的混合物，持续4周。在第0、4、11、18和29天进行血液学分析。还测定了单独用BE处理以及同时暴露于BE和ME或BE和EE的大鼠尿液中的血红蛋白（HGB）浓度。