a Faculty of Medicine , Tabriz University of Medical Sciences, Aras Branch , Tabriz , Iran and.
b Young Researchers and Elite Club, Qaemshahr Branch, Islamic Azad University , Qaemshahr , Iran.
Clin Exp Hypertens. 2016;38(1):95-9. doi: 10.3109/10641963.2015.1047946. Epub 2015 Sep 1.
Hypertension exerts a subtle impact on the brain that is revealed by diminished cognitive function. This study aimed at evaluating the association between blood pressure components and cognitive functions and cognitive reserve.
In this cross-sectional study, 500 subjects from general population were evaluated. All neuropsychological tests were negatively associated with age; memory and executive function were also positively related with education.
The hypertensives (HT) were less efficient than the normotensives (NT) in the test of memory with interference at 10 s (MI-10) (-32%, p = 0.043), clock drawing test (CLOX) (-26%, p < 0.001), and mini-mental state examination (MMSE) (-7.4%, p = 0.02). Lower MMSE, MI-10, and CLOX were predicted by higher systolic (OR, 0.94, p = 0.032; OR 0.96, p < 0.001; OR 0.94, p < 0.001) and higher pulse pressure (BP) (OR 0.95, p = 0.04; OR 0.97, p < 0.001; and OR 0.92, p < 0.001). The cognitive reserve index (CRI) was 8% lower in the HT (p = 0.04) and was predicted by higher pulse BP (OR 0.86, p < 0.001). The BP vectors of lower MMSE, MI-10, and CLOX were directed towards higher values of systolic and diastolic BP, that of low CRI towards higher systolic and lower diastolic.
This study contributes to the belief that a link exists between BP and cognition, higher values of systolic BP being associated to impaired cognitive function.
高血压对大脑产生微妙影响，导致认知功能下降。本研究旨在评估血压成分与认知功能和认知储备之间的关系。
在这项横断面研究中，评估了 500 名来自普通人群的受试者。所有神经心理学测试均与年龄呈负相关；记忆和执行功能也与教育呈正相关。
与血压正常者（NT）相比，高血压患者（HT）在 10 秒记忆干扰测试（MI-10）（-32%，p=0.043）、画钟测验（CLOX）（-26%，p<0.001）和简易精神状态检查（MMSE）（-7.4%，p=0.02）中的表现较差。较高的收缩压（OR，0.94，p=0.032；OR，0.96，p<0.001；OR，0.94，p<0.001）和较高的脉压（BP）（OR，0.95，p=0.04；OR，0.97，p<0.001；OR，0.92，p<0.001）可预测较低的 MMSE、MI-10 和 CLOX。HT 的认知储备指数（CRI）低 8%（p=0.04），且与较高的脉压 BP 相关（OR，0.86，p<0.001）。MMSE、MI-10 和 CLOX 较低的 BP 向量指向较高的收缩压和舒张压值，而较低的 CRI 则指向较高的收缩压和较低的舒张压值。
本研究证实了血压与认知之间存在联系，较高的收缩压与认知功能受损相关。
